- Evanston IL, US Devin M. Stranford - Evanston IL, US Michael J. Passineau - Wexford PA, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 38/17 A61K 51/12 A61K 9/127
Abstract:
Disclosed are extracellular vesicles (EVs), such as exosomes, comprising a heterologous cell membrane transporter protein, such as the sodium iodide symporter (NIS). Also disclosed are methods of using the disclosed EVs for delivering agents to recipient cells and methods for measuring efficacy of delivery by the EVs to the recipient cells. Also disclosed are method of making the disclosed EVs and cell lines for producing the EVs.
Ultrasound-Assisted Gene Transfer For Treatment Of Xerostomia
Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of hyposalivation and/or xerostomia are provided. In particular aspects, methods may include contacting a salivary gland of a subject with a composition containing microbubbles and a non-viral expression vector containing a nucleic acid sequence encoding a water channel, and applying ultrasound to the salivary gland.
Michael Passineau (1980-1984), Walt Kendall (1971-1975), Robert Schmidt (1972-1976), Bob Bob (1966-1970), Jennifer Polley (1990-1994), William Gavigan (1990-1994)