Medical School Northwestern Center Feinberg School of Medicine Graduated: 1970 Medical School Cleveland Metropolitan General Hospital Graduated: 1970 Medical School Walter Reed Army Medical Center Graduated: 1970
Methods of treatment and prevention of malarial infection caused by , in which combinations of atovaquone, proguanil and primaquine are administered to a patient.
Jeffrey D. Chulay - Chapel Hill NC, US Sergey Dryga - Chapel Hill NC, US Elizabeth A. Reap - Durham NC, US Robert A. Olmsted - Chapel Hill NC, US John S. Morris - Cary NC, US
Assignee:
Alpha Vax, Inc. - Research Triangle Park NC
International Classification:
A61K 39/295 A61K 39/245 C12N 7/01 C12N 15/86
US Classification:
4241991, 4241921, 4242301, 4352351, 4353201
Abstract:
The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic acid encoding cytomegalovirus pp65 and IE1 protein or immunogenic fragments thereof, and a second replicon RNA comprises nucleic acid encoding cytomegalovirus gB protein or an immunogenic fragment thereof, and wherein each of the two replicon RNAs is contained within a separate alphavirus replicon particle.
Methods And Compositions For Inducing Immune Responses And Protective Immunity By Priming With Alpha Virus Replicon Vaccines
Denise Doolan - Rockville MD, US Gary Brice - McKees Rock PA, US Carlota Dobano-Lazaro - Barcelom, ES Jeffrey Chulay - Chapel Hill NC, US Kurt Kamrud - Apex NC, US Jonathan Smith - Cary NC, US
International Classification:
A61K048/00 A61K039/002
US Classification:
424093200, 424191100
Abstract:
The inventive subject matter relates to an immunogenic composition and method of immunizing a subject against malarial disease comprising administering to the subject a priming immunization preparation comprising alphavirus replicons expressing a gene encoding a malarial antigen or combination of malarial antigens and subsequently administering to the subject a boosting immunization preparation comprising the malarial antigen(s) or an expression system containing the antigen(s). The inventive composition and methods result in a robust induction of humoral and cellular immune system responses, including CD8, CD4 and antibody responses.
Enhancement Of Vaccine-Induced Immune Responses And Protection By Heterologous Boosting With Alphavirus Replicon Vaccines
Denise Doolan - Rockville MD, US Gary Brice - , US Daniel Carucci - Washington DC, US Kurt Kamrud - Apex NC, US Jeffrey Chulay - Chapel Hill NC, US Jonathan Smith - Cary NC, US
International Classification:
A61K048/00 A61K039/12
US Classification:
424093200, 424199100
Abstract:
The inventive subject matter relates to an immunogenic composition and method of enhancing immunogenicity and protective immunity induced by any subunit or whole organism vaccine or combination of vaccines comprising administering to the subject a priming immunization preparation containing an antigen or fragment thereof, said preparation being selected from the group consisting of: a recombinant virus expression system; a recombinant protein antigen or a recombinant polypeptide; a synthetic peptide; a polynucleotide vector; a whole organism or extract and combinations thereof; and a boosting immunization of at least one alphavirus replicon containing an antigen or fragment thereof. The inventive subject matter further relates to an immunogenic composition and method of inducing an immune response that activates both cellular and humoral arms of the immune system.
Promoters, Expression Cassettes, Vectors, Kits, And Methods For The Treatment Of Achromatopsia And Other Diseases
Guo-Jie Ye - Gainesville FL, US Jeffrey D. Chulay - Gainesville FL, US
International Classification:
C12N 15/85
US Classification:
514 44 R, 536 241, 4353201
Abstract:
The present invention provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of genetic diseases that affect the cone cells of the retina.
Antigenic Determinants Recognized By Antibodies Obtained Using A Pathogenic Agent Or A Derivative Thereof That Presents A Restricted Set Of Antigens
Jeffery A. Lyon - Silver Spring MD Jeffrey L. Chulay - Washington DC Alan W. Thomas - Silver Spring MD Russell J. Howard - Los Altos Hills CA James L. Weber - Marshfield WI
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
G01N 33561 G01N 33569
US Classification:
435 7
Abstract:
A method provides peptides that are antigenic determinants identified by antibodies obtained using intact pathogenic agents that present a restricted set of antigens to surveillance by the immune system.
Promoters, Expression Cassettes, Vectors, Kits, And Methods For The Treatment Of Achromatopsia And Other Diseases
- Alachua FL, US Jeffrey D. Chulay - Southern Pines NC, US
International Classification:
C12N 15/85 C07K 14/705 A61K 48/00
Abstract:
The present invention provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of genetic diseases that affect the cone cells of the retina.