Frederick W Hartner

US Patent:

6706885, Mar 16, 2004

Filed:

Jun 5, 2002

Appl. No.:

10/191042

Inventors:

Nobuyoshi Yasuda - Mountainside NJ
Michael Palucki - Hillsborough NJ
Yi Xiao - Fanwood NJ
Frederick W. Hartner - Somerville NJ
Lushi Tan - Edison NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D21353

US Classification:

546329, 546334, 546335

Abstract:

A novel process is provided for the preparation of optionally protected 2,5-di-(3â-aminopropyl)-pyridines which are useful in the synthesis of v integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

US Patent:

7301026, Nov 27, 2007

Filed:

Apr 24, 2006

Appl. No.:

11/410179

Inventors:

Lushi Tan - Edison NJ, US
Benjamin T. Dorner - Hoboken NJ, US
Wenjie Li - Edison NJ, US
Nobuyoshi Yasuda - Mountainside NJ, US
Frederick W. Hartner - Somerville NJ, US

Assignee:

Merck & Co., Inc - Rahway NJ

International Classification:

C07D 221/18

US Classification:

546 77

Abstract:

The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

US Patent:

7709658, May 4, 2010

Filed:

Jul 21, 2006

Appl. No.:

11/988849

Inventors:

Lushi Tan - Edison NJ, US
James Christopher McWilliams - Hoboken NJ, US
Frederick W. Hartner - Somerville NJ, US
Naoki Yoshikawa - Edison NJ, US
Wenji Li - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 231/10
C07D 231/12

US Classification:

5483761, 5483771

Abstract:

The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

US Patent:

7786314, Aug 31, 2010

Filed:

Nov 3, 2004

Appl. No.:

10/578476

Inventors:

Frederick W. Hartner - Rahway NJ, US
Lushi Tan - Rahway NJ, US
Nobuyoshi Yasuda - Rahway NJ, US
Naoki Yoshikawa - Rahway NJ, US

Assignee:

Taisho Pharmaceutical Co., Ltd - Tokyo

International Classification:

C07D 319/303
C07C 61/00
C07C 69/74

US Classification:

549336, 549546, 562400, 562457, 560116, 5601191

Abstract:

Processes for the preparation of certain [3. 1. 0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.

US Patent:

20090203922, Aug 13, 2009

Filed:

Nov 17, 2006

Appl. No.:

12/085258

Inventors:

Kevin Michael Belyk - Somerset NJ, US
Benjamin Dorner - Hoboken NJ, US
Frederick Hartner - Branchburg NJ, US
Naoki Yoshikawa - Edison NJ, US
John Limanto - New Brunswick NJ, US
Lushi Tan - Edison NJ, US
Enrique Vazquez - South Plainfield NJ, US
Joseph Payack - Newbury Park CA, US

International Classification:

C07D 235/02

US Classification:

5483017

Abstract:

The present invention describes an efficient and economical process for the preparation of a 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative that is useful for the large scale production of material for preclinical and clinical use. The process of the present invention represents a convergent approach to generate the 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative in high overall yield. The compound made by the process of the invention is an inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and is therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain.

US Patent:

49635344, Oct 16, 1990

Filed:

May 19, 1989

Appl. No.:

7/353987

Inventors:

Ralph Calabria - East Brunswick NJ
Frederick W. Hartner - Somerville NJ
John T. Sisko - Lansdale PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07H 100
C07G 1700
C08B 3700
A61K 3100

US Classification:

514 54

Abstract:

A process for rendering a bacterial polysaccharide soluble in aprotic solvents by exchanging the calcium counterion of a polysaccharide calcium salt for tetra-n-alkylammonium ion by precipitation.