Douglass M Mcmanigill

US Patent:

42648173, Apr 28, 1981

Filed:

Feb 27, 1979

Appl. No.:

6/015689

Inventors:

Armand P. Neukermans - Palo Alto CA
Douglass McManigill - Palo Alto CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

H01J 3928
G01N 2762

US Classification:

250379

Abstract:

An electron capture detector in which electrons for the reaction are supplied by a filament in a cylinder through which guard gas is passed. Apertures in the cylinder permit electrons from the filament to pass into an annular space surrounding the cylinder and between it and a collector. Sample gas is passed between the aperture and the collector, the pressures being such as to be capable of minimizing the diffusion of sample gas to the filament.

US Patent:

55935648, Jan 14, 1997

Filed:

Jul 24, 1995

Appl. No.:

8/506233

Inventors:

Catherine K. Templin - Los Altos CA
Douglass McManigill - Palo Alto CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

C25B 700
G01N 2726

US Classification:

204451

Abstract:

A flow gating interface system including a first microcolumnar section, a second microcolumnar section, and a channel for interfacing a first fluid conduit and a second fluid conduit is provided. The channel, having an inwardly facing wall, encloses at least a portion each of the first microcolumnar section and the second microcolumnar section for conducting a flush fluid flow past the outlet end of the first microcolumnar section and the inlet end of the second microcolumnar section. The inwardly facing wall of the channel nonfixedly constrains and aligns the end portions of the first and second microcolumnar sections. The outlet end of the first fluid conduit is connected to and in fluid communication with the first microcolumnar section of the flow gating interface. The inlet end of the second fluid conduit is connected to and in fluid communication with the second microcolumnar section of the flow gating interface.

US Patent:

56460481, Jul 8, 1997

Filed:

Jul 24, 1995

Appl. No.:

8/505941

Inventors:

Catherine Keely Templin - Los Altos CA
Douglass McManigill - Palo Alto CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

G01N 110
G01N 3002
B01D 1508

US Classification:

436180

Abstract:

A microcolumnar analytical apparatus having a flow gating interface system for interfacing a first microcolumn and a second microcolumn is provided. The apparatus includes a flow gating interface, a first fluid conduit (e. g. a liquid chromatograph microcolumn) of a fluid sample, a flush liquid supplier, and a second fluid conduit (e. g. a capillary electrophoresis microcolumn) for analysis of the effluent fluid sample from the first fluid conduit. The flow gating interface includes a first microcolumnar section, a second microcolumnar section, and a channel. The channel, having an inwardly facing wall, encloses at least a portion each of the first microcolumnar section and the second microcolumnar section for conducting a flush fluid flow past the outlet end of the first microcolumnar section and the inlet end of the second microcolumnar section. The inwardly facing wall of the channel nonfixedly constrains and aligns said end portions of the first and second microcolumnar section due to the relative curvature and elasticity of the microcolumnar sections and the channel. The first fluid conduct is connected to and in fluid communication with the first microcolumnar section of the flow gating interface.

US Patent:

54826080, Jan 9, 1996

Filed:

Jan 19, 1993

Appl. No.:

8/006353

Inventors:

Catherine A. Keely - Cupertino CA
Douglass McManigill - Palo Alto CA
Robert R. Holloway - Montara CA

Assignee:

Hewlett Packard Company - Palo Alto CA

International Classification:

C25B 900

US Classification:

204299R

Abstract:

A system for controlling the bulk flow rate in capillary electrophoresis employs pressure to increase velocity without unacceptably increasing plate height. Thus, the system controls bulk flow over a range of velocities, independent of the chemistry of the system. Additionally, the use of pressure under certain conditions may decrease plate height and improve resolution.

US Patent:

43842984, May 17, 1983

Filed:

Mar 16, 1982

Appl. No.:

6/358551

Inventors:

Lawrence J. LaBarre - Mountain View CA
Bernard M. Oliver - Los Altos Hills CA
Charles E. Tyler - Sunnyvale CA
Dennis C. Thompson - Campbell CA
Armand P. Neukermans - Palo Alto CA
Douglass McManigill - Palo Alto CA

Assignee:

Hewlett Packard Company - Palo Alto CA

International Classification:

G01D 1516
G01D 1524

US Classification:

346129

Abstract:

An X-Y recorder for high speed plotting on a plain web, i. e. , a web without registration holes or other special means to maintain alignment of the web during plotting. Two embodiments of these plotters are disclosed with one degree of motion being achieved by moving the web and the second degree of motion being obtained by moving a pen assembly substantially perpendicularly to the movement of the web. To enhance the repeatability of the plotting on the web as it is moved back and forth, a random rough surfaced drive wheel assembly is included with that wheel surface making indentations along one surface of the driven edge of the web as it is first passed through the drive wheel assembly. Then as the web is reversed, these indentations substantially remesh with the random rough surface of the drive wheels.

US Patent:

51319977, Jul 21, 1992

Filed:

May 11, 1990

Appl. No.:

7/522278

Inventors:

John A. Christianson - Mountain View CA
Douglass McManigill - Palo Alto CA
James E. Young - La Honda CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

G01N 2726
B01D 5702

US Classification:

204299R

Abstract:

An apparatus for electrophoretic separation comprising a fixed support structure and a cassette shell which is removably attached to the support device. Within the cassette shell is a basket having symmetrically arranged ribs to secure a capillary tube in a helical configuration. The ribs have notches to receive a loop of the helically wound capillary tube. The notches of the ribs alternate in orientation with respect to the axis of the helically wound capillary tube. A quarter-turn locking member provides electrical, optical and coolant fluid communication between the cassette shell and the support device.

US Patent:

40036790, Jan 18, 1977

Filed:

Apr 2, 1975

Appl. No.:

5/564246

Inventors:

Douglass McManigill - Menlo Park CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

F04B 300
F04B 908

US Classification:

417246

Abstract:

A pumping system is provided in which a low pressure metering pump injects fluid charges into a high pressure pump which in turn operates into a high pressure load. The high pressure pump is designed to always present a low pressure at its input on its intake stroke. This insures that the metering pump will always operate into a low pressure regardless of the load, and will therefore be enabled to always accurately meter charges into the high pressure pump. In various embodiments, the high pressure pump and/or the low pressure pump include spring elements for providing well defined pumping pressures. In some embodiments, an oil reservoir and diaphragm provide a well defined pressure against which the metering pump can operate.

US Patent:

54476119, Sep 5, 1995

Filed:

Mar 15, 1994

Appl. No.:

8/213879

Inventors:

Hermanus H. Lauer - Belmont CA
Douglass McManigill - Palo Alto CA

International Classification:

G01N 2726
G01N 27447

US Classification:

2041801

Abstract:

In accordance with the present invention, a compliant pressure differential is applied across a separation column while its inlet is in a sample solution so that sample solution is introduced into the column. The profile of pressure differential over time is selected so that a desired volume of sample solution is introduced. Pressure and time are controlled with sufficient precision to yield repeatability of 5%, and preferably within 1%, by volume. The pressure differential is sufficiently low and the time sufficiently long that an acceptable velocity profile can be achieved.