Agata K Krzyzanowska

US Patent:

20160263200, Sep 15, 2016

Filed:

Oct 15, 2014

Appl. No.:

15/028997

Inventors:

- New York NY, US
Agata Krzyzanowska - Brooklyn NY, US

International Classification:

A61K 38/46
A61K 38/19
A61K 38/20
C12N 15/113
A61L 27/36
A61K 9/00
A61L 27/58
A61L 27/54
A61L 27/38
A61K 35/32
A61K 45/06

Abstract:

This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.