Zuwei Ma

US Patent:

20120156176, Jun 21, 2012

Filed:

Apr 30, 2010

Appl. No.:

13/265067

Inventors:

Kazuro Lee Fujimoto - Pittsburgh PA, US
Zuwei Ma - Woburn MA, US
Jianjun Guan - Dublin OH, US
William R. Wagner - Gibsonia PA, US

Assignee:

University of Pittsburgh-Of the Commonwealth Syste - Pittsburgh PA

International Classification:

A61K 47/32
C08F 283/02
C08G 81/02
A61K 38/19
A61K 38/02
A61K 31/56
A61K 31/7088
A61K 47/36
A61K 47/42
A61K 38/18
A61K 38/30
C12N 5/071
A61K 35/12
A61P 9/00
A61P 9/10
A61P 31/00
A61P 29/00
A61P 23/00
A61P 7/04
C08F 283/01

US Classification:

424 937, 5263075, 5253282, 5147724, 514 76, 514 11, 514169, 514 44 R, 514 91, 514 86, 435396

Abstract:

Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.