Yumei E Ye

US Patent:

20100292278, Nov 18, 2010

Filed:

May 17, 2010

Appl. No.:

12/800520

Inventors:

Yochai Birnbaum - Houston TX, US
Yumei Ye - League City TX, US

International Classification:

A61K 31/4439
A61K 31/7088
A61P 9/10

US Classification:

514342, 514 44 A

Abstract:

The present invention provides a method of treating a vascular disease or injury in an individual in need of such treatment, comprising the step of administering a compound or composition that down-regulates or decreases the activity of microRNA-29 in the individual. Also provided is a method of down-regulating or decreasing the activity of microRNA-29 in an individual in need of such treatment, comprising the step of administering a PPAR-γ agonist compound or PPAR-γ agonist containing composition that down-regulates or decreases the activity of microRNA-29 in the individual. Further provided is a method of treating a vascular disease or injury in an individual in need of such treatment, comprising the step of administering a microRNA-29 antagonist that down-regulates or decreases the activity of microRNA-29 in said individual.