William C Nason

US Patent:

RE39713, Jul 3, 2007

Filed:

Jan 23, 2003

Appl. No.:

10/351930

Inventors:

Amarpreet S. Sawhney - Lexington MA, US
Peter K. Jarrett - Sudbury MA, US
Arthur J. Coury - Boston MA, US
Ronald S. Rudowsky - Sudbury MA, US
Michelle D. Lyman - Peabody MA, US
Luis Z. Avila - Arlington MA, US
David J. Enscore - Sudbury MA, US
Stephen D. Goodrich - Tucson AZ, US
William C. Nason - Groton MA, US
Fei Yao - N. Andover MA, US
Douglas Weaver - Bedford MA, US
Shikha P. Barman - Bedford MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61F 2/02

US Classification:

424426, 424489, 424490, 5147721, 5147723, 514773, 514777, 528354, 528361, 128898, 525 541, 525 542, 525408, 525413, 525415

Abstract:

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

US Patent:

45993360, Jul 8, 1986

Filed:

Aug 8, 1983

Appl. No.:

6/521308

Inventors:

Matthew Carson - Nutley NJ
Ronald A. Le Mahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ
Jefferson W. Tilley - North Caldwell NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31505
C07D40112

US Classification:

514259

Abstract:

Compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C. sub. 1 -C. sub. 7) alkyl-N(CH. sub. 2). sub. n O-- or 2-hydroxyethoxy; n is 2 to 7; R. sub. 2 is hydrogen, lower alkyl or lower alkoxy; R. sub. 3 is hydrogen or methyl; R. sub. 4 is hydrogen or lower alkyl; R. sub. 5 is hydrogen or lower alkyl provided however if R. sub. 2 is other than hydrogen R. sub. 5 is hydrogen; m is 1 to 7; Y is ##STR2## --O-- or --S--; w is zero or one; and A is an unsubstituted or substituted aromatic 5- or 6-membered heterocyclic radical; or pharmaceutically acceptable addition salts thereof are described. The compounds of formula I are useful for treating allergic conditions and vascular disorders.

US Patent:

61770957, Jan 23, 2001

Filed:

Jan 7, 2000

Appl. No.:

9/479520

Inventors:

Amarpreet S. Sawhney - Bedford MA
Peter K. Jarrett - Sudbury MA
Arthur J. Coury - Boston MA
Ronald S. Rudowsky - Sudbury MA
Michelle D. Powell - Tewksbury MA
Luis Z. Avila - Arlington MA
David J. Enscore - Sudbury MA
Stephen D. Goodrich - Woburn MA
William C. Nason - Westford MA
Fei Yao - North Andover MA
Douglas Weaver - Bedford MA
Shikha P. Barman - Bedford MA

Assignee:

Focal, Inc - Lexington MA

International Classification:

A61F 202

US Classification:

424426

Abstract:

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

US Patent:

60835249, Jul 4, 2000

Filed:

Oct 6, 1997

Appl. No.:

8/944739

Inventors:

Amarpreet S. Sawhney - Bedford MA
David J. Enscore - Sudbury MA
Stephen D. Goodrich - Woburn MA
William C. Nason - Westford MA
Fei Yao - North Andover MA
Douglas Weaver - Bedford MA
Peter K. Jarrett - Sudbury MA
Arthur J. Coury - Boston MA
Ronald S. Rudowsky - Sudbury MA
Michelle D. Powell - Tewksbury MA
Luis Z. Avila - Arlington MA
Shikha P. Barman - Bedford MA

Assignee:

Focal, Inc. - Lexington MA

International Classification:

A61R 202
A61K 3174

US Classification:

424426

Abstract:

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

US Patent:

42811279, Jul 28, 1981

Filed:

Apr 23, 1980

Appl. No.:

6/142903

Inventors:

Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D23990

US Classification:

544287

Abstract:

Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives of the formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkykthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C. sub. 1 -C. sub. 7)alkyl-N(CH. sub. 2). sub. n O-- or 2-hydroxyethoxy; R. sub. 2 is hydrogen, lower alkyl or lower alkoxy; R. sub. 3 is hydroxy, lower alkoxy, di-(C. sub. 1 -C. sub. 7)alkyl-N(CH. sub. 2). sub. n O-- or di-(C. sub. 1 -C. sub. 7)alkyl-N(CH. sub. 2). sub. n NH--; and n is 2 to 7; provided that at least one of R. sub. 1 and R. sub. 2 is other than hydrogen, when R. sub. 3 is hydroxy, a salt thereof with a pharmaceutically acceptable base, or when R. sub. 3 is di-(C. sub. 1 -C. sub. 7)alkyl-N(CH. sub. 2). sub.

US Patent:

46281150, Dec 9, 1986

Filed:

Mar 25, 1985

Appl. No.:

6/715440

Inventors:

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07L 5976

US Classification:

562464

Abstract:

The invention relates to compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl, Z is alkylene of 1 to 10 carbon atoms, --(C*H. sub. 2). sub. 3 --C. tbd. C--, --C*H. sub. 2 --C. tbd. C--(CH. sub. 2). sub. 3 --, and --(CH. sub. 2). sub. 2 O]. sub. n (CH. sub. 2). sub. 2 -- wherein n is an integer of 1 to 3, the carbon atom marked with an asterisk is linked to the phenoxy moiety, and salts thereof with pharmaceutically acceptable bases. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A; leukotrienes C. sub. 4, D. sub. 4 and E. sub. 4), which renders them useful as agents for the treatment of allergic conditions.

US Patent:

47821760, Nov 1, 1988

Filed:

May 23, 1983

Appl. No.:

6/497375

Inventors:

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C 6976

US Classification:

560 53

Abstract:

Phenoxycarboxylic acids of the formula ##STR1## wherein R, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 R. sub. 5, Z and n are as hereinafter set forth, are as described. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A), which renders them useful as agents for the treatment of allergic conditions.

US Patent:

45074984, Mar 26, 1985

Filed:

Jan 24, 1983

Appl. No.:

6/460719

Inventors:

Matthew Carson - Nutley NJ
Ronald A. LeMahieu - North Caldwell NJ
William C. Nason - Mountain Lakes NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C 6976
C07C 6540

US Classification:

562463

Abstract:

Phenoxycarboxylic acids of the formula ##STR1## wherein R, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, Z and n are as hereinafter set forth, are as described. The compounds of formula I are antagonists of slow reacting substance of anaphylaxis (SRS-A), which renders them useful as agents for the treatment of allergic conditions.