Richard J. Armitage - Bainbridge Island WA 98110 William C. Fanslow - Federal Way WA 98023 Melanie K. Spriggs - Seattle WA 98119 Subhashini Srinivasan - Kirkland WA 98034 Marylou G. Gibson - Carlsbad CA 92009
International Classification:
C12N 512
US Classification:
435377, 435 2, 435326, 435375, 435383
Abstract:
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ligand polypeptide that stimulates B cell proliferation.
Dna Encoding Cd40 Ligand, A Cytokine That Binds Cd40
Richard J. Armitage - Bainbridge Island WA William C. Fanslow - Normandy Park WA Melanie K. Spriggs - Seattle WA Subhashini Srinivasan - Greenbrae CA Marylou G. Gibson - Carlsbad CA Arvia E. Morris - Seattle WA Jeffrey T. McGrew - Seattle WA
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
Methods Of Treating Autoimmune Disease By Administering Interleukin-17 Receptor
Isolated receptors for IL-17, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
Methods Of Treating Allergy By Administering Interleukin-17 Receptor
Zhengbin Yao - Lafayette CO, US Melanie K. Spriggs - Seattle WA, US William C. Fanslow - Federal Way WA, US
Assignee:
Immunex Corporation - Thousand Oaks CA
International Classification:
A61K 38/00
US Classification:
514 2, 530350, 530351
Abstract:
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
Mouse Cd40 Ligand-Specific Antibodies And Hybridomas
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
Methods Of Treating Asthma By Administering Interleukin-17 Receptor
Zhengbin Yao - Lafayette CO, US Melanie K. Spriggs - Seattle WA, US William C. Fanslow - Federal Way WA, US
Assignee:
Immunex Corporation - Thousand Oaks CA
International Classification:
A61K 38/00
US Classification:
514 2, 530350, 530351, 435 697
Abstract:
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
Douglas Cerretti - Seattle WA, US Luis Borges - Seattle WA, US William Fanslow - Normandy Park WA, US
International Classification:
A61K039/395 C07H021/04 C12N009/99 A61K038/55
US Classification:
514/002000, 424/130100, 435/184000, 536/023200
Abstract:
The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or conditions characterized by ocular neovascularization.
Method For Treatment Of Tumors Using Photodynamic Therapy
William Fanslow - Normandy Park WA, US Elaine Thomas - Seattle WA, US
Assignee:
IMMUNEX CORPORATION - Seattle WA
International Classification:
A61K039/395 A61N001/30 A61K038/19
US Classification:
424/085100, 424/155100, 604/020000
Abstract:
A method for treating tumor-bearing subjects that includes administering to the tumor bearing subject a therapeutically effective amount of a CD40 binding protein in conjunction with photodynamic therapy, is disclosed.
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22 Jun, 2011
Duration:
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