Wayne W Petko

US Patent:

20070128667, Jun 7, 2007

Filed:

Nov 18, 2004

Appl. No.:

10/596221

Inventors:

Jean Merrill - Whippany NJ, US
Zhengbin Yao - Sugar Land TX, US
Wayne Petko - South Bound Brook NJ, US
Olga Khorkova - North Haledon NJ, US
George Keesler - Hillsborough NJ, US
Min Wang - Blue Bell PA, US

Assignee:

AVENTIS PHARMACEUTICALS INC. - Bridgewater NJ

International Classification:

G01N 33/567
A61K 38/55
A61K 31/727

US Classification:

435007200, 514012000, 514056000

Abstract:

A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal diseases associated with free radical-mediated cell death by administering the protein, determining neuroprotective genomic targets associated with select free radical toxicity pathways by screening with the protein and using the protein to identify other compounds that modulate the biological activity of the secreted protein and the cell machinery that reacts to the secreted protein.

US Patent:

20070225330, Sep 27, 2007

Filed:

Jun 6, 2007

Appl. No.:

11/758884

Inventors:

Jean MERRILL - Morristown NJ, US
Sandrines FUNES - Nogent-sur-marne, FR
Wayne PETKO - South Bound Brook NJ, US
Karen CHANDROSS - Somerset NJ, US

Assignee:

AVENTIS PHARMACEUTICALS INC. - Bridgewater NJ

International Classification:

A61K 31/445
A61K 31/138
A61K 31/075
A61K 31/05

US Classification:

514319000, 514651000, 514721000, 514732000

Abstract:

The invention provides a new use for certain SERM-like phenylnaphthyl compounds that do not exhibit affinity for alpha or beta type estrogen receptors (ER) in the treatment of multiple sclerosis.

US Patent:

20070249706, Oct 25, 2007

Filed:

Jun 4, 2007

Appl. No.:

11/757607

Inventors:

Jean MERRILL - Whippany NJ, US
Sandrine FUNES - Nogent-sur-marne, FR
Wayne PETKO - South Bound Brook NJ, US
Karen CHANDROSS - Somerset NJ, US

Assignee:

AVENTIS PHARMACEUTICALS INC. - Bridgewater NJ

International Classification:

A61K 31/047
A61K 31/135
A61K 31/341
A61K 31/40

US Classification:

514427000, 514461000, 514646000, 514728000, 514734000

Abstract:

A method for the treatment of multiple sclerosis through the protection on the central nervous system neurons or oligodendrocytes which comprises administering to a patient having multiple sclerosis a therapeutically effective amount of a biphenyl compound as defined by formula I as follows: Wherein R, R, Rand Rare as defined herein

US Patent:

20070249732, Oct 25, 2007

Filed:

Jun 4, 2007

Appl. No.:

11/757604

Inventors:

Jean MERRILL - Whippany NJ, US
Sandrine FUNES - Nogent-sur-marne, FR
Wayne PETKO - South Bound Brook NJ, US
Karen CHANDROSS - Somerset NJ, US

Assignee:

AVENTIS PHARMACEUTICALS INC. - Bridgewater NJ

International Classification:

A61K 31/05
A61P 25/00

US Classification:

514732000

Abstract:

Certain biphenyl compounds, including 5-chloro-6-(4-hydroxyphenyl)-2-naphthalenol and 6-(4-hydroxy-phenyl)-2-naphthalene methanol are useful in the treatment of multiple sclerosis on the cellular level of the central nervous system through the protection of the patients' oligodendrocytes and neurons.

US Patent:

20080033005, Feb 7, 2008

Filed:

Jun 18, 2007

Appl. No.:

11/764259

Inventors:

Jean MERRILL - Morristown NJ, US
Sandrines FUNES - Nogent-sur-marne, FR
Wayne PETKO - South Bound Brook NJ, US
Karen CHANDROSS - Somerset NJ, US

Assignee:

AVENTIS PHARMACEUTICALS INC. - Bridgewater

International Classification:

A61K 31/4375

US Classification:

514284000

Abstract:

Certain compounds, including 5,6-dihydro-3,9-dihydroxyindolo[2,1-a-isoquinolin12yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone and arzoxifen, are useful for providing protection to oligodendrocytes and neurons of multiple sclerosis patients.