Wayne Daniel Klohs

US Patent:

6344455, Feb 5, 2002

Filed:

May 16, 2001

Appl. No.:

09/831991

Inventors:

Alexander James Bridges - Saline MI
Denise Driscoll - Ann Arbor MI
Wayne Daniel Klohs - Ypsilanti MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 315377

US Classification:

5142345, 544119

Abstract:

This invention relates to the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide that is an irreversible inhibitor of tyrosine kinases. This invention also relates to a method of treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis using the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and to a pharmaceutical composition that comprises the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide.

US Patent:

6469058, Oct 22, 2002

Filed:

Jan 19, 2001

Appl. No.:

09/744130

Inventors:

William Richard Grove - Whitmore Lake MI
Wayne Daniel Klohs - Ypsilanti MI
Ronald Lynn Merriman - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A01N 5502

US Classification:

514492, 514449, 514616, 514219

Abstract:

Acetyldinaline in combination with gemcitabine, a pharmaceutically acceptable salt thereof, capecitabine, or cisplatin is synergistic for treating cancer.

US Patent:

20030086965, May 8, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/185221

Inventors:

William Grove - Whitmore Lake MI, US
Wayne Klohs - Ann Arbor MI, US
Ronald Merriman - Ann Arbor MI, US

International Classification:

A61K033/24
A61K009/48
A61K031/7072

US Classification:

424/452000, 424/649000, 514/049000

Abstract:

Acetyldinaline in combination with gemcitabine, a pharmaceutically acceptable salt thereof, capecitabine, or cisplatin is synergistic for treating cancer.

US Patent:

20030134893, Jul 17, 2003

Filed:

Feb 20, 2003

Appl. No.:

10/286498

Inventors:

Wayne Klohs - Ypsilanti MI, US
Ronald Merriman - Ann Arbor MI, US

International Classification:

A61K031/337
A61K031/16

US Classification:

514/449000, 514/616000

Abstract:

Acetyldinaline in combination with paclitaxel and/or carboplatin is synergistic for treating cancer.

US Patent:

20030170300, Sep 11, 2003

Filed:

Oct 8, 2002

Appl. No.:

10/184309

Inventors:

William Grove - Whitmore Lake MI, US
Wayne Klohs - Ann Arbor MI, US
Ronald Merriman - Ann Arbor MI, US

International Classification:

A61K033/24
A61K009/48
A61K031/7072

US Classification:

424/452000, 424/649000, 514/049000

Abstract:

Acetyldinaline in combination with gemcitabine, a pharmaceutically acceptable salt thereof, capecitabine, or cisplatin is synergistic for treating cancer.

US Patent:

20040006042, Jan 8, 2004

Filed:

May 28, 2003

Appl. No.:

10/446466

Inventors:

David Berry - Ann Arbor MI, US
Ellen Dobrusin - Ann Arbor MI, US
Wayne Klohs - Ypsilanti MI, US
Dennis McNamara - Ann Arbor MI, US
Leslie Werbel - Ann Arbor MI, US

International Classification:

A61K031/7072
A61K031/525
A61K031/506
C 07D 4 3/04

US Classification:

514/050000, 514/251000, 514/252140, 544/295000

Abstract:

The present invention provides compounds of Formula II:

US Patent:

55978304, Jan 28, 1997

Filed:

Dec 20, 1994

Appl. No.:

8/359488

Inventors:

Wayne D. Klohs - Ann Arbor MI
Charles D. Kowal - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3144

US Classification:

514283

Abstract:

Suramin in combination with a vinca alkaloid or estramustine is synergistic for treating cancer.

US Patent:

57671109, Jun 16, 1998

Filed:

Dec 11, 1996

Appl. No.:

8/763601

Inventors:

Wayne Daniel Klohs - Ann Arbor MI
Charles Dale Kowal - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 3166
A61K 3156
A61K 31185
A61K 3117

US Classification:

514119

Abstract:

Suramin in combination with a vinca alkaloid or estramustine is synergistic for treating cancer.