Trevor L Squier

US Patent:

8308699, Nov 13, 2012

Filed:

Dec 7, 2009

Appl. No.:

12/632669

Inventors:

Zheng Zhang - Cambridge MA, US
Chad Huval - Somerville MA, US
William Shannan O'Shaughnessey - Boston MA, US
Michael Hencke - Cambridge MA, US
Trevor Squier - Peabody MA, US
Jun Li - Brookline MA, US
Michael Bouchard - Wyomissing PA, US
Christopher R. Loose - Cambridge MA, US

Assignee:

Semprus Biosciences Corp. - Cambridge MA

International Classification:

A61M 25/00
C08F 290/14
C08F 112/08
C08F 283/04
C08F 120/10
C08F 20/56
C08F 283/02
C08G 77/38

US Classification:

604265, 428413, 4284744, 428480, 442123, 5253291, 5253294, 5253303, 5253333, 5253337, 525418, 525419, 525453, 525462, 525474, 525 50, 525523, 525535, 5361231

Abstract:

Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

US Patent:

20090149673, Jun 11, 2009

Filed:

Dec 5, 2008

Appl. No.:

12/329360

Inventors:

Zheng Zhang - Cambridge MA, US
William Shannan O'Shaughnessey - Boston MA, US
Michael Hencke - Cambridge MA, US
Trevor Squier - Peabody MA, US
Christopher R. Loose - Cambridge MA, US

International Classification:

C07C 229/06

US Classification:

562553

Abstract:

Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula:where L is a linker group and Z is a non-fouling group including, but not limited to, polyethylene glycol (PEG); oligoethylene glycol (OEG); zwitterionic group, such as phosphorycholine, carboxybetaine, and sulfobetaine; groups that are hydrogen bond acceptors but not hydrogen bond donors. The non-fouling amino acids can be incorporated into a bioactive peptide as single amino acid residues, multiples amino acid residues, or as blocks of amino acids. The non-fouling amino acids, or peptides containing one or more non-fouling amino acids, can be applied to surfaces in order to improve biocompatibility, reduce thrombogenesis, and/or reduce fouling by proteins or bacteria present in solution.

US Patent:

20090155335, Jun 18, 2009

Filed:

Dec 5, 2008

Appl. No.:

12/329344

Inventors:

William Shannan O'Shaughnessey - Boston MA, US
Zheng Zhang - Cambridge MA, US
Michael Hencke - Cambridge MA, US
Kris Wood - Cambridge MA, US
Trevor Squier - Peabody MA, US
Christopher R. Loose - Cambridge MA, US

International Classification:

A61L 29/16
A61K 38/16
A61K 38/10
C07K 14/00
C07K 7/04
A61L 15/44
A61L 31/16
A61L 27/54
A61P 31/04

US Classification:

424423, 514 13, 514 12, 514 14, 530324, 530326, 530327

Abstract:

Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic.

US Patent:

20100152708, Jun 17, 2010

Filed:

Dec 7, 2009

Appl. No.:

12/632686

Inventors:

Jun Li - Brookline MA, US
Trevor Squier - Peabody MA, US
Zheng Zhang - Cambridge MA, US
Chad Huval - Somerville MA, US
William Shannan O'Shaughnessy - Boston MA, US
Michael Hencke - Cambridge MA, US
Michael Bouchard - Wyomissing PA, US
Christopher R. Loose - Cambridge MA, US

International Classification:

A61L 29/14
C08F 290/14
B32B 5/02
B32B 15/08
B32B 27/04
B32B 27/36
B32B 9/04
B32B 27/38
C08F 112/08
C08F 283/04
C08F 283/06
C08F 283/12
C08F 220/56
C08F 210/00
C07H 1/00
C07H 23/00
C08J 3/28
B05D 3/06

US Classification:

604523, 525 50, 442123, 428446, 428457, 428461, 428458, 428412, 428447, 428413, 428418, 5253333, 525453, 5253303, 5253294, 525418, 525474, 525477, 525523, 5253262, 5253337, 5361231, 536121, 522149, 427553

Abstract:

Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

US Patent:

20140045398, Feb 13, 2014

Filed:

Nov 8, 2012

Appl. No.:

13/671703

Inventors:

Chad Huval - Somerville MA, US
William Shannan O'Shaughnessey - Boston MA, US
Michael Hencke - Cambridge MA, US
Trevor Squier - Peabody MA, US
Jun Li - Brookline MA, US
Michael Bouchard - Wyomissing PA, US
Christopher R. Loose - Cambridge MA, US

Assignee:

SEMPRUS BIOSCIENCES CORPORATION - Cambridge MA

International Classification:

A61L 31/14
C09D 5/16

US Classification:

442123, 428520, 428463, 428451, 428516, 4284244, 4284763, 428483, 428447, 428412, 4284758, 428422

Abstract:

Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material