Todd C Henninger

US Patent:

6458771, Oct 1, 2002

Filed:

Apr 13, 2000

Appl. No.:

09/548584

Inventors:

Dennis J. Hlasta - Doylestown PA
Todd C. Henninger - Neshanic Station NJ
Eugene B. Grant - Edison NJ
Chaitin Khosla - Palo Alto CA
Daniel T. W. Chu - Santa Clara CA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
Kosan Biosciences, Inc. - Raritan NJ

International Classification:

A61K 3170

US Classification:

514 29, 536 74

Abstract:

A series of ketolide antibacterials in the macrolide family of the formula: intermediates used in their manufacture and pharmaceutical compositions containing them. The compounds are erythromycin analogues useful in the treatment of bacterial and protozoal infections and in the treatment of other conditions involving gastric motility.

US Patent:

6472372, Oct 29, 2002

Filed:

Feb 1, 2001

Appl. No.:

09/773788

Inventors:

Todd C. Henninger - Neshanic Station NJ
Xiaodong Xu - Bridgewater NJ

Assignee:

Ortho-McNeil Pharmaceuticals, Inc. - Raritan NJ

International Classification:

A61K 3170

US Classification:

514 29, 536 79, 536 185

Abstract:

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R , R , R , R , R , R , X, Xâ, Y, and Yâ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

US Patent:

6579880, Jun 17, 2003

Filed:

Jun 6, 2001

Appl. No.:

09/875840

Inventors:

Todd C. Henninger - Neshanic Station NJ
Dennis J. Hlasta - Doylestown PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 31496

US Classification:

5142531, 51425403, 51425404, 514318, 514326, 514340, 514364, 514378, 544364, 544367, 546194, 546209, 5462694, 5462721, 548131, 548247, 548248

Abstract:

The invention relates to isoxazole and oxadiazole compounds of Formulae I and II, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of IL-8 and are thus useful as anti-inflammatory agents for a variety of diseases.

US Patent:

6590083, Jul 8, 2003

Filed:

Oct 18, 2000

Appl. No.:

09/691540

Inventors:

Dennis Hlasta - Doylestown PA
Todd C. Henninger - Neshanic Station NJ
Eugene B. Grant - Edison NJ
Chaitin Khosla - Palo Alto CA
Daniel T. W. Chu - Santa Clara CA
Gary Ashley - Alameda CA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07H 1708

US Classification:

536 74

Abstract:

The present invention includes compounds of the formula wherein: X is hydrogen or halide; R is hydrogen, acyl, or a hydroxy protecting group; R is hydrogen, hydroxyl, or âOR wherein R is a substituted or unsubstituted moiety selected from the group consisting of C -C alkyl, C -C alkenyl, C -C alkynyl, aryl, heterocyclo, aryl(C -C )alkyl, aryl(C -C )alkenyl, aryl(C -C )alkynyl, heterocyclo(C -C )alkyl, heterocyclo(C -C )alkenyl, and heterocyclo(C -C )alkynyl; R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of methyl; C -C alkyl, C -C alkenyl, C -C alkynyl, aryl, heterocyclo, aryl(C -C )alkyl, aryl(C -C )alkenyl, aryl(C -C )alkynyl, heterocyclo(C -C )alkyl, heterocyclo(C -C )alkenyl, and heterocyclo(C -C )alkynyl; and, R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of C -C alkyl, C -C alkenyl, C -C alkynyl, aryl, heterocyclo, aryl(C -C )alkyl, aryl(C -C )alkenyl, aryl(C -C )alkynyl, heterocyclo(C -C )alkyl, heterocyclo(C -C )alkenyl, and heterocyclo(C -C )alkynyl; and the pharmaceutically acceptable salts, esters and pro-drug forms thereof. These compounds possess anti-infective activity and are useful for the treatment of bacterial and protozoal infections.

US Patent:

6613747, Sep 2, 2003

Filed:

Dec 5, 2001

Appl. No.:

10/011937

Inventors:

Todd C. Henninger - Neshanic Station NJ
Xiaodong Xu - Bridgewater NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raitan NJ

International Classification:

A61K 3170

US Classification:

514 29, 536 71, 536 185

Abstract:

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R , R , R , R , R , R , X, Xâ, Y, and Yâ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

US Patent:

6713455, Mar 30, 2004

Filed:

Sep 16, 2002

Appl. No.:

10/244184

Inventors:

Todd C. Henninger - High Bridge NJ
Mark J. Macielag - Branchburg NJ
Deodialsingh Guiadeen - Linden NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3170

US Classification:

514 29, 536 72, 536 74

Abstract:

6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R , R , R R , and R are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

US Patent:

6825170, Nov 30, 2004

Filed:

Nov 21, 2002

Appl. No.:

10/301412

Inventors:

Todd C. Henninger - High Bridge NJ
Mark J. Macielag - Branchburg NJ
Manomi A. Tennakoon - Bridgewater NJ
Xiaodong Xu - Bridgewater NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3170

US Classification:

514 29, 536 74, 536 185

Abstract:

6-O-Acyl ketolide antibacterials of the formula: wherein R , R , R , R , W, X, Xâ, Y, and Yâ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

US Patent:

6825172, Nov 30, 2004

Filed:

May 28, 2003

Appl. No.:

10/447058

Inventors:

Todd C. Henninger - High Bridge NJ
Mark J. Macielag - Branchburg NJ
Brett A. Marinelli - Hamilton NJ
Bin Zhu - Hillsborough NJ

Assignee:

Janssen Pharmaceutica, NV - Beerse

International Classification:

A61K 3170

US Classification:

514 29, 536 73, 536 74

Abstract:

3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R , W, R , R , R , R , X, Xâ, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.