Timothy Yeatman - Greenville SC, US Andrey Loboda - Philadelphia PA, US Hongyue Dai - Chestnut Hill MA, US
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc. - Tampa FL Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C12Q 1/68
US Classification:
506 9
Abstract:
In one aspect, methods, markers, and expression signatures are disclosed for assessing the degree to which a cell sample has epithelial cell-like properties or mesenchymal cell-like properties. In another aspect, methods are provided for predicting cancer patient prognosis based on whether the cancer is classified as having a high or low EMT Signature Score.
Method Of Predicting Non-Response To First Line Chemotherapy
Timothy J. Yeatman - Spartanburg SC, US Deepak Agrawal - Tampa FL, US Adil Daud - Hillsborough CA, US
Assignee:
UNIVERSITY OF SOUTH FLORIDA - Tampa FL H.Lee Moffitt Cancer Center and Research Institute, Inc. - Tampa FL
International Classification:
G01N 33/574 G01N 27/447 C12Q 1/68
Abstract:
The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis using measurements of a plurality of gene products in a cell sample taken from said patient, said gene products being respectively products of at least 1 of the genes listed in Table 1, or respective functional equivalents thereof, wherein said good prognosis predicts a positive response to standard chemotherapy regimens, and said poor prognosis predicts non-responsiveness. Provided herein, the invention includes a gene signature to predict which patients will to benefit from standard colon cancer therapy; alternatively, patients who are classified as non-responders may be more likely to benefit from a novel agent such as a Notch inhibitor.
Name / Title
Company / Classification
Phones & Addresses
Timothy Yeatman Associate Center Director For Clinical Investigations
University of South Florida Colleges, Universities, and Professional Scho...
4202 E Fowler Ave Adm, Tampa, FL 33620
Timothy J. Yeatman President, Treasurer, Director, Secretary