Steve Granick - Champaign IL, US Svetlana A. Sukhishvili - Maplewood NJ, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
B05D 3/00 B05D 7/00
US Classification:
427212, 427214, 427352, 427353
Abstract:
A film contains a first polymer having a plurality of hydrogen bond donating moieties, and a second polymer having a plurality of hydrogen bond accepting moieties. The second polymer is hydrogen bonded to the first polymer.
Methods For Controlled Release Of Molecules From Layered Polymer Films
Svetlana Sukhishvili - Maplewood NJ, US Eugenia Kharlampieva - Jersey City NJ, US Vladimir Izumrudov - Moscow, RU
Assignee:
Trustees of Stevens Institute of Technology
International Classification:
A61K009/70
US Classification:
424/443000
Abstract:
Low molecular weight molecules are selectively released from a layered polymer film having a net excess charge by introducing at least one other type of molecule that binds reversibly to the film and thereby reduces the net excess charge. Oligomeric and polymeric molecules, whether synthetic or natural, are selectively and reversibly released from the layered polymer film in response to variation in ionic strength in the environment of the film. Such molecules are also selectively and reversibly released from the layered polymer film in response to changes in the pH in the environment of the film.
Patterned Polymer Microgel And Method Of Forming Same
Matthew Libera - New Providence NJ, US Svetlana Sukhishvili - Maplewood NJ, US Peter Krsko - New Brunswick NJ, US
International Classification:
B05D003/00 G21H001/00
US Classification:
428195100, 427551000
Abstract:
Surface-patterned microgels are formed by treating polymer films like electron-beam photoresists, but without destroying or removing the patterned microgels from their substrate. Focused electron beams are used to create patterned microgels on surfaces where the enhanced spatial resolution can be exploited to create gels with characteristic length scales relevant to cellular and sub-cellular processes. Varying the beam intensity allows control of the concentration of proteins that adhere to the resulting microgel. The process can be used to precisely locate the adhesive junction between cells and a substrate and to confine cell growth within defined areas.
Capsules Of Multilayered Neutral Polymer Films Associated By Hydrogen Bonding
Micro-, and nano-scale capsules comprising neutral (uncharged) polymeric layers, layers associated by hydrogen bonding and methods for making such capsules. The capsules of the invention are layered upon a core particle using a layer-by layer-technique. The capsule walls of the capsules of the invention give a tailored response to external stimuli.
Matthew Libera - New Providence NJ, US Svetlana Sukhishvili - Maplewood NJ, US Peter Krsko - New Brunswick NJ, US Ye Hong - Pleasanton CA, US
International Classification:
C12M 3/00
US Classification:
428195100
Abstract:
Nanometer-scale hydrogels are formed from a polymer film by exposing said film to a focused electron beam of 1 to 10 nm diameter. The hydrogels may be formed in regular patterns, such as arrays, or in irregular patterns. The hydrogels have a plurality of functional groups that can form covalent bonds with proteins while preserving the natural functionality of the proteins. Such functionalized nanohydrogels may serve as a substrate for attachment of other proteins or cells, or may be used in other biological applications.
Functionalization Of Air Hole Arrays Of Photonic Crystal Fibers
Henry Du - Short Hills NJ, US Svetlana Sukhishvili - Maplewood NJ, US
International Classification:
G01N 21/00
US Classification:
422058000, 977957000
Abstract:
An inventive sensor is used in combination with spectroscopic techniques to detect, identify and quantify ultratrace (ppt to ppb) quantities of analytes in air or water samples. The sensor preferably comprises a photonic crystal fiber having an air hole cladding with functionalized air holes. Surface-enhanced Raman spectroscopy is a preferred spectroscopic technique. In such applications, the air holes of the fiber may be functionalized by adsorbing a self-assembled monolayer on their inner surfaces, and immobilizing metallic nanoparticles to the monolayer. The invention has chemical and biomedical applications, and utility in detecting chemical and biological agents used in warfare.
A film contains a first polymer having a plurality of hydrogen bond donating moieties, and a second polymer having a plurality of hydrogen bond accepting moieties. The second polymer is hydrogen bonded to the first polymer.