Susan L Hafenstein

US Patent:

20210372948, Dec 2, 2021

Filed:

Aug 11, 2021

Appl. No.:

17/399492

Inventors:

- University Park PA, US
Susan Hafenstein - Lemont PA, US

International Classification:

G01N 23/04
C07K 1/00
C07K 14/47

Abstract:

Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.

US Patent:

20200124544, Apr 23, 2020

Filed:

Mar 16, 2018

Appl. No.:

16/494502

Inventors:

- University Park PA, US
Susan Hafenstein - Lemont PA, US

International Classification:

G01N 23/04
C07K 1/00
C07K 14/47

Abstract:

Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration.