Stephen A Coulter

US Patent:

52449130, Sep 14, 1993

Filed:

Nov 19, 1991

Appl. No.:

7/794544

Inventors:

Stephen L. Coulter - Irvine CA
Kenneth G. Mayhan - Irvine CA
Christy L. H. Oviatt - Mission Viejo CA
Steven R. Morehead - Riverside CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K 3144
A61K 3114

US Classification:

514358

Abstract:

Compositions and methods for dissolving calculi deposits in humans are disclosed. The compositions include solutions of quaternary ammonium salts and are particularly effective for the contact dissolution of pigment portions of biliary tract calculi such as gallstones. The solutions preferably further include mineral chelating agent and disulfide bond cleaving agent to aid in deaggregating mineral components and glycoprotein components of calculi.

US Patent:

58916580, Apr 6, 1999

Filed:

Jun 27, 1996

Appl. No.:

8/671378

Inventors:

Stanley M. Klainer - Henderson NV
Stephen L. Coulter - Henderson NV
Geoffrey F. Hewitt - Henderson NV

Assignee:

FCI--FiberChem, Inc. - Las Vegas NV

International Classification:

G01N 3353
G01N 33543
G01N 33552

US Classification:

435 793

Abstract:

Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit accurate sensitive qualitative and quantitative information to be obtained without human participation. All of the chemistry-biochemistry is an inherent part of the sensor. A direct reaction occurs when the sample (antigen) is brought in contact with the sensor. The sensitivity of the competitive immunoassay optical sensor is controlled and increased by selecting a tag for the antigen or altering the attachment of a tag to an antigen so that the binding of tagged antigen to an antibody is decreased relative to the binding of untagged antigen to the antibody. The user can vary size, molecular weight and geometric configuration of the tagged antigen. This can be accomplished by selecting the proper tag or by attaching the indicator material to the antigen through a spacer or by attaching the tag directly to the antigen and attaching a compound of proper molecular weight and size elsewhere.

US Patent:

57802513, Jul 14, 1998

Filed:

Dec 30, 1996

Appl. No.:

8/774389

Inventors:

Stanley M. Klainer - Henderson NV
Stephen L. Coulter - Henderson NV
Geoffrey F. Hewitt - Henderson NV

Assignee:

FCI FiberChem, Inc. - Las Vegas NV

International Classification:

G01N 3353
G01N 33552

US Classification:

435 793

Abstract:

Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit accurate sensitive qualitative and quantitative information to be obtained without human participation. All of the chemistry-biochemistry is an inherent part of the sensor. A direct reaction occurs when the sample (antigen) is brought in contact with the sensor. The sensitivity of the competitive immunoassay optical sensor is controlled and increased by selecting a tag for the antigen or altering the attachment of a tag to an antigen so that the binding of tagged antigen to an antibody is decreased relative to the binding of untagged antigen to the antibody. The user can vary size, molecular weight and geometric configuration of the tagged antigen. This can be accomplished by selecting the proper tag or by attaching the indicator material to the antigen through a spacer or by attaching the tag directly to the antigen and attaching a compound of proper molecular weight and size elsewhere.

US Patent:

57374570, Apr 7, 1998

Filed:

Jan 16, 1996

Appl. No.:

8/587231

Inventors:

Devinder P. Saini - Henderson NV
Stanley M. Klainer - Henderson NV
Stephen L. Coulter - Henderson NV

Assignee:

FCI - FiberChem, Inc. - Las Vegas NV

International Classification:

G02B 600

US Classification:

385 12

Abstract:

Waveguide sensors are formed on a chip package which contains at least one source and at least one detector. Simple waveguide elements are mounted on the chip. Waveguide defining elements can also be formed integrally with the chip package so that simple waveguide bodies can be inserted or removed. Various geometries of source, reference detector, and sensing detector can be produced. A liquid waveguide sensor is formed by filling a waveguide channel with a liquid reagent or reagents homogeneously dispersed in sol-gels. Sensing waveguides are made of or contain chemistries or biochemistries or are uncoated. Reference waveguides are made of or contain chemistries, biochemistries or materials which are inert to the analyte (sample) of interest. The chip geometries are such that absorption, fluorescence, and refractive index measurements can be made.

US Patent:

52740285, Dec 28, 1993

Filed:

Dec 6, 1990

Appl. No.:

7/622917

Inventors:

William J. Bertrand - Mission Viejo CA
Stephen L. Coulter - Irvine CA
Cary Reich - Laguna Hills CA
Paul DeAntonio - Westminister CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

C08F28300
C08F28312

US Classification:

525 17

Abstract:

In an improved method for producing a surface graft of a hydrophilic polymer upon a preformed solid or semi-solid polymer substrate having hydroperoxide groups along its surface, n-vinyl pyrrolidone is utilized as the surface-grafting monomer, the substrate is selected to be insoluble in n-vinyl pyrrolidone, and the polymerization is carried out in aqueous alkaline conditions utilizing a combination of metal salts to provide a variable valence metal ion in a reduced state capable of oxidizing to suppress homopolymerization of the monomer in the solution. When the substrate is at least partially soluble in the n-vinyl pyrrolidone, an ethylenically unsaturated monomer having a higher reactivity with the substrate than n-vinyl pyrrolidone is added to the alkaline polymerization solution as a "seeding" monomer. Addition of the "seeding" monomer results in a surface-grafted copolymer effectively externalized from the substrate.