Soya Gamsey - Huntington Beach CA, US Ritchie A. Wessling - Watsonville CA, US
Assignee:
Glumetrics Inc. - Irvine CA
International Classification:
C07F 5/02 A61B 5/145
US Classification:
546 13, 424 96, 424 91
Abstract:
Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
Pyridinium Boronic Acid Quenchers For Use In Analyte Sensors
Soya Gamsey - Huntington Beach CA, US Ritchie A. Wessling - Watsonville CA, US
Assignee:
Glumetrics, Inc. - Irvine CA
International Classification:
C07F 5/02 G01N 33/66
US Classification:
546 13, 436 14, 424 91
Abstract:
Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
Optical Sensor Configuration For Ratiometric Correction Of Blood Glucose Measurement
David R. Markle - Berwyn PA, US Soya Gamsey - Huntington Beach CA, US Thomas A. Peyser - Menlo Park CA, US
Assignee:
Glumetrics, Inc. - Irvine CA
International Classification:
A61B 5/00
US Classification:
600316, 600309, 600364, 600365, 600366
Abstract:
Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.
Measurement Devices And Methods For Measuring Analyte Concentration Incorporating Temperature And Ph Correction
Matthew A. Romey - Newport Beach CA, US Soya Gamsey - Huntington Beach CA, US Thomas A. Peyser - Menlo Park CA, US
Assignee:
Glumetrics, Inc. - Irvine CA
International Classification:
G06F 17/11 G06F 17/50 A61B 5/05
US Classification:
702 23, 702 19, 600345, 600347
Abstract:
Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.
Polyviologen Boronic Acid Quenchers For Use In Analyte Sensors
Soya Gamsey - Huntington Beach CA, US Ritchie A. Wessling - Watsonville CA, US
Assignee:
Glumetrics Inc. - Irvine CA
International Classification:
G01N 21/64 C07F 5/02
US Classification:
436 95, 546 13
Abstract:
The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.
THOMAS A. PEYSER - MENLO PARK CA, US SOYA GAMSEY - HUNTINGTON BEACH CA, US MATTHEW A. ROMEY - NEWPORT BEACH CA, US DAVID R. MARKLE - BERWYN PA, US
Assignee:
GLUMETRICS, INC. - IRVINE CA
International Classification:
G06F 19/00 G01N 33/48
US Classification:
702 19, 702 24, 702 85
Abstract:
Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.
Matthew A. Romey - Newport Beach CA, US Soya Gamsey - Huntington Beach CA, US David R. Markle - Berwyn PA, US
Assignee:
Glumetrics, Inc. - Irvine CA
International Classification:
A61B 5/1473 A61L 33/00 G01N 21/00
US Classification:
600309, 427 212, 422 8205
Abstract:
Embodiments of the present invention relate to analyte sensors comprising a heparin benzalkonium antithrombogenic coating, and methods of coating analyte sensors.
Identification Of Aberrant Measurements Of In Vivo Glucose Concentration Using Temperature
Thomas A. Peyser - Menlo Park CA, US Richard E. Purvis - Pasadena CA, US David R. Markle - Berwyn PA, US Soya Gamsey - Huntington Beach CA, US Matthew A. Romey - Newport Beach CA, US
Assignee:
GLUMETRICS, INC. - Irvine CA
International Classification:
A61B 5/145
US Classification:
600365
Abstract:
Disclosed herein are methods and systems for generating an estimate of an in vivo analyte concentration and identifying whether the estimate is aberrant. In some embodiments, the system includes a sensor comprising an analyte sensor and a temperature sensing element, and a control unit programmed to identify changes in temperature that may indicate a non-physiologic condition (and result in an aberrant glucose measurement). In some embodiments, the methods include generating an estimate of analyte concentration at a particular time using the analyte sensor, and generating first and second signals indicative of temperature using the temperature sensing element. In some embodiments the methods include identifying the estimate of analyte concentration as aberrant if the magnitude of the difference between the first and second signals indicative of temperature exceeds a threshold value.
PROFUSA since 2011
VP Chemistry Development
Glumetrics, Inc. 2009 - 2011
Director of Sensor Development
Glumetrics, Inc. 2007 - 2009
Senior Scientist
Glumetrics, Inc. 2006 - 2007
Research Chemist
Geron 1998 - 2001
Research Associate
Education:
University of California, Santa Cruz 2001 - 2006
Ph.D., Organic Chemistry
Reed College 1993 - 1997
B.A., Chemistry
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