Siddhesh D Patil

US Patent:

20230102273, Mar 30, 2023

Filed:

Mar 27, 2017

Appl. No.:

16/088096

Inventors:

- Osaka, JP
Masahiro MIZUNO - Osaka, JP
Kazuhiro MAEDA - Osaka, JP
Tsuneo YASUMA - Osaka, JP
Misaki HOMMA - Kanagawa, JP
Yuya OGURO - Kanagawa, JP
Naohiro TAYA - Kanagawa, JP
Lei ZHU - Bedford MA, US
John Daniel BAILEY - Cambridge MA, US
Marianne LANGSTON - Cambridge MA, US
Siddhesh Dinanath PATIL - Cambridge MA, US
Shruti GOUR - Watertown MA, US
Lilly ROY - Boston MA, US

International Classification:

C07D 471/08
A61K 9/48

Abstract:

The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I).0.5HO; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.

US Patent:

20210299255, Sep 30, 2021

Filed:

Jul 19, 2019

Appl. No.:

17/260318

Inventors:

- Cambridge MA, US
Gregory ST. LOUIS - Cambridge MA, US
Eva WILLIAMS - Cambridge MA, US
Narinder SINGH - Cambridge MA, US
Siddhesh PATIL - Cambridge MA, US

International Classification:

A61K 39/395
C07K 16/28
A61K 47/02
A61K 47/26
A61K 47/12
A61K 9/00

Abstract:

Stable pharmaceutical compositions containing an anti-FcRn antibody are described and characterized.