Shari L Deninno

US Patent:

52179605, Jun 8, 1993

Filed:

May 3, 1991

Appl. No.:

7/695176

Inventors:

Paul A. Lartey - Wadsworth IL
Ramin Faghih - Gurnee IL
Shari DeNinno - Gales Ferry CT

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3170
C07H 1708

US Classification:

514 29

Abstract:

Antibacterial compounds are disclosed having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R. sup. 1 is --NR. sup. 4 R. sup. 6, where R. sup. 4 and R. sup. 6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R. sup. 4 and R. sup. 6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R. sup. 2 is selected from the group consisting of hydrogen, --OH and, when R. sup. 3 is methylene, oxygen so as to form an epoxide; and R. sup. 3 is selected from the group consisting of --CH. sub. 2 OH, --NR. sup. 4 R. sup. 6, --(CH. sub. 2). sub. n NR. sup. 4 R. sup. 6 and, when R. sup. 2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R. sup. 4 and R. sup. 6 are as previously defined, with the proviso that when R. sup. 2 is --OH, R. sup.