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Samuel Zalipsky

age ~68

from Redwood City, CA

Also known as:
  • Sam Zalipsky
  • Shmuel Zalipsky
  • Samuel Lynn
Phone and address:
1202 Truman St, Redwood City, CA 94061
650-306-9553

Samuel Zalipsky Phones & Addresses

  • 1202 Truman St, Redwood City, CA 94061 • 650-306-9553 • 650-925-4846
  • 4936 Knowlson Ter, Fremont, CA 94555 • 510-925-4846
  • 2234 Strawberry Ct, Edison, NJ 08817 • 732-925-4846
  • 2243 Strawberry Ct, Edison, NJ 08817 • 732-925-4846
  • Princeton, NJ
  • 1202 Truman St, Redwood City, CA 94061 • 650-218-7643

Work

  • Company:
    Independent consultant
    2012
  • Position:
    Pharmaceutical, drug delivery, and biotechnology consultant

Education

  • Degree:
    Doctorates, Doctor of Philosophy
  • School / High School:
    University of Minnesota
    1981 to 1986
  • Specialities:
    Chemistry

Skills

Drug Delivery • Biotechnology • Protein Chemistry • Chemistry • Formulation • R&D • Pharmaceutical Industry • Drug Discovery • Drug Development • Life Sciences • Biopharmaceuticals • Technology Transfer • Polymer Chemistry • Clinical Development • Biochemistry • Pharmaceutics • Organic Chemistry • Chromatography • Patents • Product Development • Lifesciences • Peptides • Oncology • Commercialization • Nanoparticles • Analytical Chemistry • Cancer • Biopolymers • Biocompatibility • Technology Evaluation • Purification • Chemical Biology • Team Leadership • Antibodies • Synthetic Chemistry • Carbohydrate Chemistry • Peptide Synthesis • Intellectual Property • Due Diligence • Supramolecular Chemistry • Technology Scouting • Ind • Technology Development

Languages

English • Russian • Hebrew • German • Spanish

Emails

Industries

Pharmaceuticals

Isbn (Books And Publications)

Poly(ethylene Glycol): Chemistry and Biological Applications

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Author
Samuel Zalipsky

ISBN #
0841235376

Us Patents

  • Releasable Linkage And Compositions Containing Same

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  • US Patent:
    6342244, Jan 29, 2002
  • Filed:
    Apr 21, 2000
  • Appl. No.:
    09/556056
  • Inventors:
    Samuel Zalipsky - Redwood City CA
  • Assignee:
    Alza Corporation - Mountain View CA
  • International Classification:
    A61K 9127
  • US Classification:
    424450, 424 851, 205254, 514 1, 530336, 536 84
  • Abstract:
    A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
  • Conjugate Having A Cleavable Linkage For Use In A Liposome

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  • US Patent:
    6365179, Apr 2, 2002
  • Filed:
    Apr 21, 2000
  • Appl. No.:
    09/556610
  • Inventors:
    Samuel Zalipsky - Redwood City CA
    Alberto A. Gabizon - Jerusalem, IL
  • Assignee:
    ALZA Corporation - Mountain View CA
  • International Classification:
    A61K 9127
  • US Classification:
    424450, 424 851, 205254, 530336, 536 84, 514 1
  • Abstract:
    Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.
  • Neutral Lipopolymer And Liposomal Compositions Containing Same

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  • US Patent:
    6586001, Jul 1, 2003
  • Filed:
    Jul 13, 2000
  • Appl. No.:
    09/615552
  • Inventors:
    Samuel Zalipsky - Redwood City CA
  • Assignee:
    Alza Corporation - Palo Alto CA
  • International Classification:
    A61K 9127
  • US Classification:
    424450, 242 121, 242 9321, 242 951, 4284022
  • Abstract:
    Liposomes containing PEG-substituted neutral lipopolymers provide similar circulation times to liposomes incorporating conventional, negatively charged PEG-substituted phospholipids. Use of the uncharged lipopolymers can also present advantages in terms of interactions with cell surfaces and reduced leakage of charged substances, particularly cationic drugs, from the liposomes. The lipopolymers are of the formula: wherein each of R and R is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms, n is about 10 to about 300, Z is selected from the group consisting of hydroxy, alkoxy, benzyloxy, carboxylic ester, sulfonic ester, alkyl or aryl carbonate, amino, and alkylamino, and the linkage L is selected from the group consisting of (i) —X—(C O)—Y—CH —, (ii) —X—(C O)—, and (iii) —X—CH —, wherein X and Y are independently selected from oxygen, NH, and a direct linkage.
  • Enhanced Circulation Effector Composition And Method

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  • US Patent:
    6586002, Jul 1, 2003
  • Filed:
    Jun 8, 2001
  • Appl. No.:
    09/877978
  • Inventors:
    Samuel Zalipsky - Redwood City CA
    Martin C. Woodle - Menlo Park CA
    Francis J. Martin - San Francisco CA
    Yechezkel Barenholz - Jerusalem, IL
    Herve Bercovier - Jerusalem, IL
  • Assignee:
    Alza Corporation - Mountain View CA
  • International Classification:
    A61K 9127
  • US Classification:
    424450, 424812, 424 852, 424 854, 424 858, 530319, 5303911, 530350, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331
  • Abstract:
    A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
  • Releasable Linkage And Compositions Containing Same

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  • US Patent:
    6605299, Aug 12, 2003
  • Filed:
    Oct 15, 2001
  • Appl. No.:
    09/982336
  • Inventors:
    Samuel Zalipsky - Redwood City CA
  • Assignee:
    Alza Corporation - Mountain View CA
  • International Classification:
    A61K 9127
  • US Classification:
    424450, 424 851, 205254, 514 1, 530336, 536 84
  • Abstract:
    A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
  • Therapeutic Liposome Composition And Method

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  • US Patent:
    6660525, Dec 9, 2003
  • Filed:
    Feb 10, 2000
  • Appl. No.:
    09/501857
  • Inventors:
    Francis J. Martin - San Francisco CA
    Samuel Zalipsky - Redwood City CA
    Shi Kun Huang - Castro Valley CA
  • Assignee:
    Alza Corporation - Mountain View CA
  • International Classification:
    C12N 1586
  • US Classification:
    435458, 435375, 424450, 530402, 530403
  • Abstract:
    A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.
  • Releasable Linkage And Compositions Containing Same

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  • US Patent:
    6849270, Feb 1, 2005
  • Filed:
    Feb 21, 2003
  • Appl. No.:
    10/371169
  • Inventors:
    Samuel Zalipsky - Redwood City CA, US
  • Assignee:
    Alza Corporation - Mountain View CA
  • International Classification:
    A61K 9127
    A61K 3800
    C08B 1100
    A01N 6100
  • US Classification:
    424450, 424 851, 205254, 530336, 536 84, 514 1
  • Abstract:
    A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
  • 10139483Therapeutic Liposome Composition And Method Of Preparation

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  • US Patent:
    6936272, Aug 30, 2005
  • Filed:
    Dec 10, 2001
  • Appl. No.:
    10/016324
  • Inventors:
    Francis J. Martin - San Francisco CA, US
    Samuel Zalipsky - Redwood City CA, US
  • Assignee:
    ALZA Corporation - Mountain View CA
  • International Classification:
    A61K009/127
  • US Classification:
    424450, 424 43, 424 46
  • Abstract:
    A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposome outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a method for using the composition to deliver a compound to target cells, and a method for selecting suitable hydrophobic polymers for use in the composition.
Name / Title
Company / Classification
Phones & Addresses
Samuel Zalipsky
CTO
INTRADIGM CORPORATION
Commercial Physical Research · Research and Development in the Physical, Engineering, and L
2400 Broadway STE 200, Redwood City, CA 94063
3350 W Bayshore Rd, Palo Alto, CA 94303
2400 Broadway St, Redwood City, CA 94063
650-855-9696, 650-855-9633

Resumes

Samuel Zalipsky Photo 1

Pharmaceutical, Drug Delivery, And Biotechnology Consultant

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Location:
San Francisco, CA
Industry:
Pharmaceuticals
Work:
Independent Consultant
Pharmaceutical, Drug Delivery, and Biotechnology Consultant

Phaserx 2010 - 2011
Vice President, Research

Silence Therapeutics Plc 2007 - 2010
Vice President, Technology Development

Johnson & Johnson 1999 - 2007
Senior Res Fellow and Assoc Director

Sequus Pharmaceuticals 1992 - 1999
Senior Research Investigator
Education:
University of Minnesota 1981 - 1986
Doctorates, Doctor of Philosophy, Chemistry
The Hebrew University of Jerusalem 1978 - 1981
Master of Science, Masters, Chemistry
The Hebrew University of Jerusalem
Bachelors, Bachelor of Science, Biochemistry, Chemistry
Skills:
Drug Delivery
Biotechnology
Protein Chemistry
Chemistry
Formulation
R&D
Pharmaceutical Industry
Drug Discovery
Drug Development
Life Sciences
Biopharmaceuticals
Technology Transfer
Polymer Chemistry
Clinical Development
Biochemistry
Pharmaceutics
Organic Chemistry
Chromatography
Patents
Product Development
Lifesciences
Peptides
Oncology
Commercialization
Nanoparticles
Analytical Chemistry
Cancer
Biopolymers
Biocompatibility
Technology Evaluation
Purification
Chemical Biology
Team Leadership
Antibodies
Synthetic Chemistry
Carbohydrate Chemistry
Peptide Synthesis
Intellectual Property
Due Diligence
Supramolecular Chemistry
Technology Scouting
Ind
Technology Development
Languages:
English
Russian
Hebrew
German
Spanish

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Samuel Zalipsky Photo 2

Samuel Zalipsky Redwood ...

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