University of Colorado Anschutz Medical Campus
Professor
University of Colorado Denver Business School
Professor
3M Health Care Jun 2001 - Jun 2004
Senior Immunologist
Education:
University of Minnesota 1993 - 1997
Doctorates, Doctor of Philosophy, Immunology
University of Minnesota 1988 - 1992
Bachelors, Bachelor of Science, Biology
Skills:
Molecular Biology Cell Biology Science Immunology Cell Culture Flow Cytometry Animal Models Lifesciences Molecular Cloning Cancer Elisa Western Blotting Pcr Cell In Vivo
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
Immunostimulatory Compositions And Methods Of Stimulating An Immune Response
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
Immunostimulatory Regimen Comprising Administering Type 1 Interferon And Agonistic Anti-Cd40 Antibody
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
Immunostimulatory Regimen Comprising Administering Type 1 Interferon And Agonistic Anti-Cd40 Antibody
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
Tlr9 Agonist And Cd40 Agonist Immunostimulatory Combinations
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.
Methods And Compositions For Enhancing Immune Response
Richard Miller - Maplewood MN, US Mark Tomai - Woodbury MN, US Ross Kedl - Denver CO, US Isidro Zarraga - Minneapolis MN, US Ronnie Ortiz - Apple Valley MN, US James Stoesz - Inver Grove Heights MN, US
International Classification:
A61K031/44
US Classification:
424/423000
Abstract:
Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.