John T. Henri - Longmont CO, US James D. McChesney - Boulder CO, US Sylesh K. Venkataraman - Boulder CO, US Rodger L. Lamb - Westminster CO, US Jonathan E. Foster - Arvada CO, US Christian M. Sumner - Boulder CO, US Shangping Ye - Centennial CO, US
International Classification:
C07D 233/02 C07D 305/14 C07D 309/02 C07F 9/06
US Classification:
5483345, 549510, 549358, 564 12
Abstract:
The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds, including taxane derivatives, and convergent processes for the preparation of these taxane derivatives and their intermediates.
Convergent Process For The Synthesis Of Taxane Derivatives
James D. McChesney - Boulder CO, US John T. Henri - Longmont CO, US Sylesh K. Venkataraman - Longmont CO, US Rodger L. Lamb - Westminster CO, US Jonathan E. Foster - Boulder CO, US Christian M. Summer - Boulder CO, US Shangping Ye - Florence SC, US
James D. McChesney - Boulder CO, US Rodger Lamb - Westminster CO, US Stanley Kahler - Litteton CO, US
Assignee:
Tapestry Pharmaceuticals, Inc. - Boulder CO
International Classification:
A61K 31/357 C07D 493/04 A61P 35/00
US Classification:
514452, 549358
Abstract:
The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula:wherein Rand Rare each selected from H, alkyl, alkenyl or aryl; Ris hydroxyl or OP; Ris OH or RCOO; Ris alkyl, alkenyl or aryl, Rand Rare each independently selected from H, alkyl or alkenyl. The compounds of the present application may particularly be 9,10-α,α-OH taxane analogs that are formed by a process starting with a standard taxane as the starting compound.
Biologically Active Taxane Analogs And Methods Of Treatment
James D. McChesney - Boulder CO, US Rodger Lamb - Westminster CO, US Stanley Kahler - Littleton CO, US
Assignee:
Tapestry Pharmaceuticals, Inc. - Boulder CO
International Classification:
A61K 31/357 C07D 493/04 A61P 35/00 A61P 35/02
US Classification:
514452, 549358
Abstract:
The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula:wherein Rand Rare each selected from H, alkyl, alkenyl or aryl; Ris hydroxyl or OP; Ris OH or RCOO; Ris alkyl, alkenyl or aryl, Rand Rare each independently selected from H, alkyl or alkenyl. The compounds of the present application may particularly be 9,10-α,α-OH taxane analogs that are formed by a process starting with a standard taxane as the starting compound.
Molecular Constructs Suitable For Targeted Conjugates
The present invention relates generally to effective drug-linker constructs suitable for conjugation with ligands. The present invention also discloses methods of conjugating these constructs with peptides to form the compound of formula I. These methods are readily extended to any hydroxyl, amine or sulfur bearing biologically active molecules.
Terumo Bct
Project Manager
Allosource Sep 2018 - Oct 2019
Senior Project Manager
Corden Pharma - A Full-Service Cdmo Nov 2017 - Sep 2018
Process Scientist and Project Manager
Pfizer Jun 2014 - Nov 2017
Process Chemist and Project Manager
Cedarburg Pharmaceuticals, A Division of Amri Mar 2011 - Nov 2012
Process Chemist
Education:
Metropolitan State University of Denver 1994 - 1999
Bachelors, Bachelor of Science, Chemistry
Skills:
Organic Synthesis Chromatography Chemistry Hplc Gmp Medicinal Chemistry Pharmaceutical Process Development Gas Chromatography Purification Technology Transfer Process Simulation Uv/Vis Lc Ms Filtration High Performance Liquid Chromatography Organic Chemistry Data Analysis Leadership Crystallization Project Management Cross Functional Team Leadership
Certifications:
Certified Associate In Project Management (Capm) Project Management Professional (Pmp)® License 1670266 Project Management Institute, License 1670266
Rodger Lamb 1985 graduate of Longmont High School in Longmont, CO is on Classmates.com. See pictures, plan your class reunion and get caught up with Rodger and other high school ...
Rodger Lamb's Public Profile on Plaxo. Plaxo helps members like Rodger Lamb keep in touch with the people who really matter, helping them to connect, keep each other's contact data ...
Googleplus
Rodger Lamb
Youtube
Roger Lamb talks about the Ladder of Loyalty ...
www.clockworksal... Here, Roger Lamb talks about turning prospects to...
Category:
People & Blogs
Uploaded:
25 May, 2011
Duration:
1m 24s
6. The Lord is My Shepherd: REQUIEM by John R...
Performed by the Chancel Choir - Burbank First United Methodist Church...
Category:
Music
Uploaded:
30 Oct, 2010
Duration:
5m 4s
The Gondoliers - I Am a Courtier Grave and Se...
The Duke of Plaza Toro (Jonathan Fulcher) gives advice to Marco (Jason...
Category:
Entertainment
Uploaded:
08 Oct, 2009
Duration:
3m 58s
The Gondoliers - We're Called Gondolieri
Jason Sly (Marco) and Roger Lamb (Giuseppe) in The Gondoliers - Southa...
Category:
Entertainment
Uploaded:
08 Oct, 2009
Duration:
2m 20s
EL SHADDAI Gospel Music Ministry - Worthy is ...
This song is interpreted by the EL SHADDAI Gospel Music Ministry condu...
Category:
Music
Uploaded:
16 Mar, 2010
Duration:
4m 57s
The Gondoliers - In a Contemplative Fashion
Don Alhambra (Nick Hollands) comperes the Grand Inquisitor TV Chat Sho...