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Robert B Lobell

age ~58

from Blue Bell, PA

Also known as:
  • Robert Lobell
  • Robt Lobell
513 Brights Ln, Blue Bell, PA 19422215-542-9573

Robert Lobell Phones & Addresses

  • 513 Brights Ln, Blue Bell, PA 19422 • 215-542-9573
  • Penllyn, PA
  • Watertown, MA
  • Acton, MA
  • Lower Gwynedd, PA
  • Mahopac, NY
  • Needham, MA
  • Lansdale, PA

Industries

Pharmaceuticals

Us Patents

  • Covalent Dimer Of Kit Ligand

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  • US Patent:
    5525708, Jun 11, 1996
  • Filed:
    Mar 28, 1994
  • Appl. No.:
    8/220379
  • Inventors:
    Karl H. Nocka - Harvard MA
    Robert B. Lobell - Watertown MA
  • Assignee:
    CytoMed, Inc. - Cambridge MA
  • International Classification:
    C07K 1452
  • US Classification:
    530409
  • Abstract:
    A modified form of KL, the ligand for the c-Kit proto-oncogene, has been prepared wherein the protein is stabilized by an intermolecular covalent linkage. The protein can be prepared by expression of a recombinant protein which is dissolved in denaturant and refolded under conditions resulting in a disulfide linked dimer. Examples demonstrate the purification and characterization of this disulfide-linked cysteine dimer kit ligand (KL-CD) which contains at least one intermolecular disulfide bond and has at least ten-fold greater activity in promoting cell proliferation than native, non-covalently linked KL, as measured in in vitro assays.

Resumes

Robert Lobell Photo 1

Director At Merck

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Location:
Greater Philadelphia Area
Industry:
Pharmaceuticals

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Robert Lobell Photo 2

Robert Lobell

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Classmates

Robert Lobell Photo 3

William C. Bryant High Sc...

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Graduates:
Robert Lobell (1944-1948),
Roberto Pazmino (1995-1999),
Stephen Applebaum (1958-1961),
Sylvia Baratz (1957-1961)

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