Yusuke Nakamura - Tokyo, JP Yo Matsuo - Kanagawa, JP Shoji Hisada - Kanagawa, JP Feryan Ahmed - Latham NY, US Raymond Huntley - Albany NY, US David M. Jenkins - Cohoes NY, US Robert B. Kargbo - Guilderland NY, US Wenge Cui - Clifton Park NY, US Polivina Jolicia F. Gauuan - Schenectady NY, US Joel R. Walker - Schenectady NY, US Helene Decornez - Clifton Park NY, US Mahender Gurram - Guilderland NY, US
- Cambridge MA, US Boyd L. Harrison - Princeton Junction NJ, US Albert Jean Robichaud - Boston MA, US Francesco G. Salituro - Marlborough MA, US Robert Jason Herr - Voorheesville NY, US Robert Borbo Kargbo - Guilderland NY, US
International Classification:
C07J 43/00 A61K 45/06 A61K 31/58
Abstract:
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R, R, R, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
- Madison WI, US Sergei Saveliev - Madison WI, US Zhiyang Zeng - Madison WI, US Robert Kargbo - Madison WI, US Hui Wang - Madison WI, US Sergiy Levin - Madison WI, US Valerie Ressler - Madison WI, US Jun Zhang - Madison WI, US Ce Shi - Madison WI, US Harry Tetsuo Uyeda - Madison WI, US Jean Osterman - Madison WI, US Min Zhou - Madison WI, US Prabin Rai - Madison WI, US Wenhui Zhou - Madison WI, US
- Cambridge MA, US Boyd L. Harrison - Princeton Junction NJ, US Albert Jean Robichaud - Cambridge MA, US Francesco Gerald Salituro - Marlborough MA, US Robert Jason Herr - Voorheesville NY, US Robert Borbo Kargbo - Guilderland NY, US
Assignee:
Sage Therapeutics, Inc. - Cambridge MA
International Classification:
C07J 43/00
Abstract:
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R, R, R, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
Tricyclic Compounds And Pbk Inhibitors Containing The Same
- Kanagawa, JP Matsuo YO - Kanagawa, JP Shoji HISADA - Kanagawa, JP Feryan AHMED - Latham NY, US Raymond HUNTLEY - Albany NY, US David M. JENKINS - Cohoes NY, US Robert B. KARGBO - Guilderland NY, US Wenge CUI - Clifton Park NY, US Polivina Jolicia F. GAUUAN - Schenectady NY, US Joel R. WALKER - Schenectady NY, US Helene DECORNEZ - Clifton Park NY, US Mahender GURRAM - Guilderland NY, US
International Classification:
C07D 495/04 C07D 213/64 C07D 401/04 C07D 519/00
Abstract:
Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.