Robert T Goegelman from 437 Academy Ter, Tremley, NJ 07036, Phone: 908-486-7625

Immunosuppressive Cyclosporin Analogs With Modified Amino Acids At Position-8
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US Patent:

51225115, Jun 16, 1992
Filed:

Feb 27, 1990
Appl. No.:

7/485920
Inventors:

Arthur A. Patchett - Westfield NJ
David Taub - Metuchen NJ
Robert T. Goegelman - Linden NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07K 512
C07K 764
A61K 3700
US Classification:

514 11
Abstract:

New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala]. sup. 8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.

Thienamycin Production
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US Patent:

40060608, Feb 1, 1977
Filed:

Nov 18, 1975
Appl. No.:

5/632938
Inventors:

Jean S. Kahan - Rahway NJ
Frederick M. Kahan - Rahway NJ
Edward O. Stapley - Metuchen NJ
Robert T. Goegelman - Linden NJ
Sebastian Hernandez - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C12D 914
US Classification:

195 80R
Abstract:

The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.

Process For Producing Antibiotics By Cultivation Of Streptomyces Flavogriseus
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US Patent:

42359678, Nov 25, 1980
Filed:

Apr 6, 1979
Appl. No.:

6/027642
Inventors:

Patrick J. Cassidy - Rahway NJ
Robert T. Goegelman - Linden NJ
Edward O. Stapley - Metuchen NJ
Sebastian Hernandez - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C12P 1718
US Classification:

435119
Abstract:

The antibiotics MSD 890A. sub. 1 and MSD 890A. sub. 3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A. sub. 1 and 890A. sub. 3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.

Antibiotics
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US Patent:

40815480, Mar 28, 1978
Filed:

Sep 3, 1976
Appl. No.:

5/720483
Inventors:

Jean S. Kahan - Rahway NJ
Frederick M. Kahan - Rahway NJ
Edward O. Stapley - Metuchen NJ
Robert T. Goegelman - Linden NJ
Sebastian Hernandez - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3140
US Classification:

424274
Abstract:

The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.

Antibiotics
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US Patent:

39503577, Apr 13, 1976
Filed:

Nov 25, 1974
Appl. No.:

5/526992
Inventors:

Jean S. Kahan - Rahway NJ
Frederick M. Kahan - Rahway NJ
Edward O. Stapley - Metuchen NJ
Robert T. Goegelman - Linden NJ
Sebastian Hernandez - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D20712
US Classification:

26032627
Abstract:

The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.

Isolation Of Non-Ionic Lipophilic Materials On Macroreticular Polymeric Absorbents
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US Patent:

43992749, Aug 16, 1983
Filed:

Jul 2, 1981
Appl. No.:

6/279633
Inventors:

Robert T. Goegelman - Linden NJ
Laszlo R. Treiber - Gillette NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07H 1708
US Classification:

536 71
Abstract:

Non-ionic, lipophilic substances are isolated from aqueous or aqueous-organic solution by treatment with a macroreticular polymeric absorbent followed by elution with additional or a different organic solvent.

Avermectin Bioconversion Products
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US Patent:

46669370, May 19, 1987
Filed:

Feb 20, 1986
Appl. No.:

6/830333
Inventors:

Robert T. Goegelman - Linden NJ
Edward S. Inamine - Rahway NJ
Raymond F. White - Englishtown NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D49322
A61K 31365
US Classification:

514450
Abstract:

There are disclosed novel compounds which are derived from 22,23-dihydro avermectin Bla aglycone, 13-deoxy-22,23 dihydro overmectin Bla aglycone and 13-deoxy-22,23-dihydro overmectin Blb aglycone. The six compounds are hydroxy adducts of the substrate avermectin compound at the 12a, 24, 24a, 26, 26a and 27 positions. The hydroxy adducts are prepared by incubating the substrate with the microorganism Cunninghamella blakesleeana and isolating the hydroxy adducts from the fermentation broth. The compounds are highly potent antiparasitic, insecticidal and anthelmintic agents.

Method For The Production Of A Modified "8-Amino Acid" Cyclosporin Derivative
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US Patent:

53189019, Jun 7, 1994
Filed:

Jul 10, 1992
Appl. No.:

7/911433
Inventors:

Arthur A. Patchett - Westfield NJ
Raymond F. White - Englishtown NJ
Robert T. Goegelman - Linden NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C12P 2104
US Classification:

435 711
Abstract:

A cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.

Robert T Goegelman