Robert A Aarhus

age ~62

from Coon Rapids, MN

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Robert Aarhus Phones & Addresses

Research

Cyclic-Adp-Ribose Analogs
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US Patent:

6593307, Jul 15, 2003
Filed:

Oct 27, 2000
Appl. No.:

09/698611
Inventors:

Timothy F. Walseth - Roseville MN
Antonio De Flora - Genoa, IT
Elena Zocchi - Genoa, IT
Marina Podesta - Genoa, IT
Long Wong - Roseville MN
Robert A. Aarhus - Coon Rapids MN
Hon Cheung Lee - Woodbury MN
Assignee:

Regents of the University of Minnesota - Minneapolis MN
International Classification:

A61K 3170
US Classification:

514 47, 514 46, 514 45, 536 2611
Abstract:

The present invention provides a compound of formula I: wherein A, D, R , and R are as defined in the specification; or a salt or a detectably labeled derivative thereof. The invention also provides methods of using the compound of formula I or a salt or a detectably labeled derivative thereof for promoting the proliferation of hemopoietic progenitor cells without cell differentiation.

Caged Nucleotides
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US Patent:

58722432, Feb 16, 1999
Filed:

Jun 30, 1995
Appl. No.:

8/497183
Inventors:

Kyle R. Gee - Springfield OR
Hon Cheung Lee - Woodbury MN
Robert Aarhus - Brooklyn Park MN
Richard P. Haugland - Eugene OR
Timothy F. Walseth - Roseville MN
Richard M. Graeff - St. Paul MN
Assignee:

Molecular Probes, Inc. - Eugene OR
The Regents of the University of Minnesota - Minneapolis MN
International Classification:

C07H 100
C07H 2100
US Classification:

536 2623
Abstract:

The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD. sup. +, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.

Cyclic Adp Ribose Antagonists
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US Patent:

54866049, Jan 23, 1996
Filed:

Nov 1, 1993
Appl. No.:

8/148646
Inventors:

Timothy F. Walseth - Roseville MN
Robert A. Aarhus - Brooklyn Park MN
Assignee:

Regents of the University of Minnesota - Minneapolis MN
International Classification:

C07H 1923
A61K 5100
US Classification:

536 2613
Abstract:

Cyclic ADP-ribose (cADPR) analogs block cADPR from releasing Ca. sup. +2, and also inhibit cADPR from potentiating Ca. sup. +2 release induced by either divalent cations or by caffeine. 8-amino-cADPR and two other 8-substituted analogs were also synthesized. Both 8-Br- and 8-azido-cADPR were also antagonists, although with less potency than 8-amino-cADPR. These results show that alterations at the 8-position of the adenine group do not inhibit cADPR from binding to its receptor but do eliminate the ability of the metabolite to activate the Ca. sup. +2 release mechanism.