Richard P Woodworth

US Patent:

20030045560, Mar 6, 2003

Filed:

Jun 13, 2002

Appl. No.:

10/170558

Inventors:

Thomas Commons - Wayne PA, US
Susan Croce - Lambertville NJ, US
Richard Woodworth - Eagleville PA, US
Eugene Trybulski - Princeton Junction NJ, US
Hassan Elokdah - Yardley PA, US
David Crandall - Doylestown PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D261/18
C 07D 4 3/02
A61K031/421
A61K031/415
A61K031/195

US Classification:

514/381000, 514/374000, 514/406000, 514/419000, 514/469000, 514/563000, 548/248000, 548/252000, 548/374100, 548/494000, 549/444000, 562/450000

Abstract:

This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl, furanyl, benzofuranyl, indolyl, pyrazolyl, oxazolyl, fluorenyl, phenylcycloalkane where the cycloalkane can be cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl and Ar can be optionally substituted by 1 to 3 groups selected from C-Calkyl, C-Calkoxy, hydroxy, phenyl-(CH)—, phenyl-(CH)O—, C-Ccycloalkyl, —(CH)—C-Ccycloalkyl, halogen, C-Cperflouroalkyl and C-Cperfluoroalkoxy where phenyl can be substituted with from 1 to 3 groups selected from C-Calkyl, C-Calkoxy, phenyl, halogen, trifluoromethyl or trifluoromethoxy; Ris hydrogen, C-Calkyl or phenyl-(CH)— where phenyl can be substituted with C-Calkyl, C-Calkoxy, halo, trifluoromethyl or trifluoromethoxy; Rand Rare H, C-Calkyl, phenyl-(CH)—, halo and C-Cperfluoroalkyl where phenyl can be substituted with C-Calkyl, C-Calkoxy, halo, trifluoromethyl or trifluoromethoxy; Ris —CHRCOH or —CH-tetrazole where Ris H or benzyl; and n=0 or 1; or a pharmaceutically acceptable salt or ester form thereof.

US Patent:

20060052348, Mar 9, 2006

Filed:

Aug 22, 2005

Appl. No.:

11/208777

Inventors:

Thomas Commons - Wayne PA, US
Richard Woodworth - North Wales PA, US

Assignee:

WYETH - Madison NJ

International Classification:

A61K 31/4439
A61K 31/427
A61K 31/422
C07D 417/02
C07D 413/02

US Classification:

514092000, 514340000, 514365000, 514374000, 546271400, 548202000, 548215000

Abstract:

The present invention relates to oxazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.

US Patent:

20060276464, Dec 7, 2006

Filed:

May 10, 2006

Appl. No.:

11/432788

Inventors:

Ariamala Gopalsamy - Mahwah NJ, US
William Moore - Collegeville PA, US
Jeffery Kern - Gilbertsville PA, US
Albert Molinari - Pottstown PA, US
Mengxiao Shi - New Rochelle NY, US
Gregory Welmaker - Collegeville PA, US
Mathew Wilson - Royersford PA, US
Girija Krishnamurthy - Chestnut Ridge NY, US
Thomas Commons - Wayne PA, US
Michael Webb - Douglassville PA, US
Richard Woodworth - North Wales PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/537
A61K 31/538
A61K 31/495
A61K 31/445
A61K 31/4172
A61K 31/40
A61K 31/18

US Classification:

514230500, 514252120, 514396000, 514602000, 514237500, 514317000, 514352000, 544158000, 544399000, 546229000, 564086000, 514408000, 544092000

Abstract:

Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided: which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

US Patent:

20080045518, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/891821

Inventors:

Thomas Joseph Commons - Wayne PA, US
Andrew Fensome - Wayne PA, US
Gavin David Heffernan - Florence NJ, US
Casey Cameron McComas - Phoenixville PA, US
Richard Page Woodworth - North Wales PA, US
Michael Byron Webb - Douglassville PA, US
Michael Anthony Marella - Limerick PA, US
Edward George Melenski - Collegeville PA, US
Ronald Charles Bernotas - Royersford PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/5355
A61P 15/00
A61P 35/00
A61P 5/00
C07D 413/04

US Classification:

5142288, 544 96

Abstract:

Compounds of the following structure are described:wherein R-R, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

US Patent:

20080045556, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/891748

Inventors:

Thomas Joseph Commons - Wayne PA, US
Andrew Fensome - Wayne PA, US
Gavin David Heffernan - Florence NJ, US
Casey Cameron McComas - Phoenixville PA, US
Richard Page Woodworth - North Wales PA, US
Michael Byron Webb - Douglassville PA, US
Michael Anthony Marella - Limerick PA, US
Edward George Melenski - Collegeville PA, US
Ronald Charles Bernotas - Royersford PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/42
A61K 31/41
A61K 31/425
A61K 31/44
A61P 15/00
A61P 35/00
A61P 5/00
C07D 277/28
C07D 285/08
C07D 413/02

US Classification:

514278, 514361, 514365, 514374, 546 16, 548128, 548205, 5483111

Abstract:

Compounds of the following structure are described:wherein R, R, R, R, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

US Patent:

20080045560, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/891727

Inventors:

Thomas Joseph Commons - Wayne PA, US
Andrew Fensome - Wayne PA, US
Gavin David Heffernan - Florence NJ, US
Casey Cameron McComas - Phoenixville PA, US
Richard Page Woodworth - North Wales PA, US
Michael Byron Webb - Douglassville PA, US
Michael Anthony Marella - Limerick PA, US
Edward George Melenski - Collegeville PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/454
A61K 31/4025
A61K 31/403
A61K 31/42
A61K 31/421
A61K 31/4245
A61K 31/425
A61P 15/18
C07D 405/04
C07D 417/14
C07D 417/04
C07D 413/14
C07D 413/04
C07D 409/14
C07D 409/04
C07D 405/14
A61P 5/32
A61K 31/426
A61K 31/433
A61K 31/435
A61K 31/4412
A61K 31/4525
A61K 31/4535

US Classification:

514299, 514326, 514361, 514364, 514365, 514372, 514377, 514380, 514414, 514422, 546183, 546209, 546212, 546214, 546 26, 548128, 548133, 548195, 548214, 548233, 548245, 548466, 548517, 548527

Abstract:

Compounds of the following structure are described:wherein R-R, R, R, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

US Patent:

20080045577, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/891728

Inventors:

Thomas Joseph Commons - Wayne PA, US
Andrew Fensome - Wayne PA, US
Gavin David Heffernan - Florence NJ, US
Casey Cameron McComas - Phoenixville PA, US
Richard Page Woodworth - North Wales PA, US
Michael Byron Webb - Douglassvile PA, US
Michael Anthony Marella - Limerick PA, US
Edward George Melenski - Collegeville PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/427
A61P 15/00
C07D 417/04

US Classification:

514370, 514365, 548198, 548203

Abstract:

Compounds of the following structure are described:wherein R-R, R, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

US Patent:

20080045578, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/891747

Inventors:

Thomas Joseph Commons - Wayne PA, US
Andrew Fensome - Wayne PA, US
Gavin David Heffernan - Florence NJ, US
Casey Cameron McComas - Phoenixville PA, US
Richard Page Woodworth - North Wales PA, US
Michael Byron Webb - Douglassville PA, US
Michael Anthony Marella - Limerick PA, US
Edward George Melenski - Collegeville PA, US
Ronald Charles Bernotas - Royersford PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/428
A61P 15/00
C07D 417/04

US Classification:

514371, 548150

Abstract:

Compounds of the following structure are described:wherein R-R, R, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.