Renato V Iozzo

US Patent:

6524573, Feb 25, 2003

Filed:

Sep 22, 2000

Appl. No.:

09/668084

Inventors:

Renato V. Iozzo - Gladwyne PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 6300

US Classification:

424 932, 424 9321, 4353201, 435325, 435455, 514 44

Abstract:

A method of suppressing tumor growth is provided wherein decorin gene or its gene products are administered so that epidermal growth factor receptor activity is induced. This specific mechanism has been linked to tumor growth suppression.

US Patent:

6821947, Nov 23, 2004

Filed:

Dec 4, 2001

Appl. No.:

10/006011

Inventors:

Renato V. Iozzo - Gladwyne PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A01N 3718

US Classification:

514 2, 530350

Abstract:

Angiogenesis is a highly regulated process, yet many diseases are driven by unregulated angiogenesis. For example, the growth and metastasis of tumors is dependent on the growth of new blood vessels, which nurture the tumor by providing not only a growth-conducive environment but also a route by which metastatic cells can escape. The present invention provides an angiogenesis inhibiting agent endorepellin, its fragments or derivatives, or analogs thereof, which inhibit angiogenesis. The invention disclosed herein provides a novel therapeutic approach to the treatment of tumors, and other angiogenesis-mediated diseases or conditions, by inhibiting the generation of new blood vessels. The present invention also provides anti-endorepellin, its fragments or derivatives, or analogs thereof, antibodies for the detection, diagnosis and monitoring of angiogenesis-mediated diseases or conditions.

US Patent:

53546660, Oct 11, 1994

Filed:

Dec 29, 1992

Appl. No.:

7/999462

Inventors:

Keith G. Danielson - Rosemont PA
Renato V. Iozzo - Villanova PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

C12P 2100
C12N 506

US Classification:

435 703

Abstract:

EHS murine tumor cells express basement membrane proteins such as laminin, entactin, collagen and proteoglycan. An immortal mammalian cell line designated BAM having phenotypic characteristics of EHS murine tumor cells may be prepared by culture of EHS cells in nutrient culture medium supplemented with low concentration of mammalian serum. BAM cells express basement membrane proteins in vitro.