Reevis S Alphin

US Patent:

47228342, Feb 2, 1988

Filed:

Mar 5, 1986

Appl. No.:

6/836521

Inventors:

Lina C. Teng - Richmond VA
Stephen C. Bearekman - Richmond VA
Lennox B. Turnbull - Richmond VA
Reevis S. Alphin - Richmond VA
William L. Smith - Richmond VA

Assignee:

A. H. Robins Company, Incorporated - Richmond VA

International Classification:

A61K 3144

US Classification:

424 10

Abstract:

A method of controlling emesis caused by anticancer drugs with 2-alkoxy-N-(1-azabicyclo[2. 2. 2]oct-3-yl) benzamide-N-oxides having the formula: ##STR1## wherein R. sub. 1 is loweralkyl, and R. sub. 2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

US Patent:

43438040, Aug 10, 1982

Filed:

Mar 4, 1980

Appl. No.:

6/127153

Inventors:

Harry R. Munson - Richmond VA
Reevis S. Alphin - Richmond VA

Assignee:

A. H. Robins Company, Inc. - Richmond VA

International Classification:

A61K 3147

US Classification:

424258

Abstract:

A method of reducing gastric acidity and treating peptic ulcers and pharmaceutical compositions therefor with certain 4-amino-3-quinolinecarboxylic acids and esters are disclosed. Illustrative of compounds useful in the method which relies on activity as antisecretory activity is the novel compound ethyl 8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate which has the formula: ##STR1##.

US Patent:

39937674, Nov 23, 1976

Filed:

Nov 18, 1975

Appl. No.:

5/633043

Inventors:

Reevis Stancil Alphin - Richmond VA
David Andrew Droppleman - Richmond VA

Assignee:

A. H. Robins Company, Incorporated - Richmond VA

International Classification:

A61K 3140
A61K 3142
A61K 31415

US Classification:

424272

Abstract:

Methods of treating symptomatic conditions of inflammation due to chronic and acute rheumatic and degenerative joint disease with a combination of indomethacin or phenylbutazone and a phenoxymethyl-2-oxazolidinone resulting in beneficial reduction in side effects of ulceration and bleeding in the lower intestinal tract normally associated with indomethacin and phenylbutazone and compositions containing the combination are disclosed.

US Patent:

41090055, Aug 22, 1978

Filed:

May 11, 1977

Appl. No.:

5/795827

Inventors:

Carl D. Lunsford - Richmond VA
Reevis S. Alphin - Richmond VA

Assignee:

A. H. Robins Company, Inc. - Richmond VA

International Classification:

A61K 3140

US Classification:

424274

Abstract:

Pyrrolidinyl benzamides represented by the formula: ##STR1## wherein R is methyl or cycloalkyl having 3 to 12 carbon atoms; R. sup. 1 is hydrogen or methyl and the pharmaceutically acceptable salts thereof are disclosed in methods which increase the rate of gastric emptying in mammals.

US Patent:

47175630, Jan 5, 1988

Filed:

Mar 5, 1986

Appl. No.:

6/836518

Inventors:

Reevis S. Alphin - Richmond VA
William L. Smith - Richmond VA
Harry R. Munson - Richmond VA
Robert F. Boswell - Richmond VA

Assignee:

A. H. Robins Company, Inc. - Richmond VA

International Classification:

A61K 3144

US Classification:

424 10

Abstract:

A method of controlling emesis caused by non-platinum anti-cancer drugs with 2-alkoxy-N-(1-azabicyclo[2. 2. 2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R. sub. 1 is loweralkyl; and R. sub. 2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

US Patent:

40369579, Jul 19, 1977

Filed:

Nov 18, 1975

Appl. No.:

5/633044

Inventors:

Reevis Stancil Alphin - Richmond VA
John Wesley Ward - Richmond VA

Assignee:

A. H. Robins Company, Inc. - Richmond VA

International Classification:

A61K 31625

US Classification:

424232

Abstract:

Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenoxy- and substituted-phenoxy alcohols, carbamates, aminoalcohols, carbamoylalcohols, oxazolidinones, pyrrolidines, thiosemicarbazides and aminoalkylacetamides. The compounds act systemically to ameliorate gastric bleeding otherwise caused by aspirin.

US Patent:

40256243, May 24, 1977

Filed:

Nov 18, 1975

Appl. No.:

5/633042

Inventors:

Reevis Stancil Alphin - Richmond VA
William John Welstead - Richmond VA

Assignee:

A. H. Robins Company, Incorporated - Richmond VA

International Classification:

A61K 3117
A61K 31615
A61K 31625

US Classification:

424233

Abstract:

Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: ##STR1## wherein Z is selected from the group consisting of --NHR. sup. 2 or ##STR2## and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R. sup. 1, R. sup. 2, R. sup. 3 and R. sup. 4 are selected from the group consisting of hydrogen and lower-alkyl, where R. sup. 3 and R. sup. 4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino.