Randal J Schoepp

US Patent:

20070218516, Sep 20, 2007

Filed:

Mar 20, 2006

Appl. No.:

11/384712

Inventors:

Thomas Palys - Cascade MD, US
Randal Schoepp - Frederick MD, US
Kara Schmid - Frederick MD, US

International Classification:

G01N 33/554
C07H 21/04
C12P 21/06
C07K 16/12

US Classification:

435007320, 530388400, 435326000, 536023530, 435320100, 435069100

Abstract:

In this application is described the production of recombinant, chimeric, humanized antibodies specific for both BoNt/A and BoNT/B. The humanized antibodies were converted from a mouse anti-BoNT/A/B Fab fragment into a whole human IgG1 antibody. The antibodies are useful in assays for detecting human exposure to BoNT/A and BoNT/B.

US Patent:

20190178881, Jun 13, 2019

Filed:

Nov 2, 2018

Appl. No.:

16/178635

Inventors:

- Fort Detrick MD, US
Charles J. Shoemaker - Stephen's City VA, US
Randal J. Schoepp - Frederick MD, US
Connie S. Schmaljohn - Middletown MD, US

International Classification:

G01N 33/543
G01N 33/531
G01N 33/569
G01N 33/68

Abstract:

Described herein are virus-like particles (VLPs) that were generated to present the viral glycoprotein antigens on their surface, coupled to magnetic fluorescent microspheres to create VLP-conjugated microspheres (VCMs) and methods of making them. These VCMs were stable when lyophilized and stored at 37 C. and able to detect antibodies in non-human primate (NHP) and human clinical sera at dilutions of 1×10and 1×10, respectively. Methods are also disclosed for detecting an immune response using VCMs.