Ramesh S Ayyala

US Patent:

20090124955, May 14, 2009

Filed:

Nov 24, 2008

Appl. No.:

12/277139

Inventors:

Ramesh S. Ayyala - New Orleans LA, US

International Classification:

A61F 9/00
A61M 1/00
A61F 2/14

US Classification:

604 8, 604285, 604288, 604521, 623 41

Abstract:

An ophthalmological device comprises an implant member carrying an antifibrotic agent that is released slowly over a prolonged period when inserted into a wound in an eye produced by surgery. The member is placed in the vicinity of a wound created during the surgery to inhibit inflammatory cell proliferation, thereby preventing the growth of fibrous tissue after the eye surgery.

US Patent:

20220233564, Jul 28, 2022

Filed:

Jan 25, 2022

Appl. No.:

17/583781

Inventors:

- Tampa FL, US
Srinivas Tipparaju - Tampa FL, US
Kevin Sneed - Tampa FL, US
Manas Biswal - Tampa FL, US
Ramesh Ayyala - Tampa FL, US
Radouil Tzekov - Tampa FL, US

International Classification:

A61K 31/706
A61K 9/00
A61K 31/573

Abstract:

The present disclosure provides for an ophthalmological composition comprising remdesivir and an ophthalmologically suitable carrier, and the use thereof for treating and preventing a coronavirus infection and treating conjunctivitis.

US Patent:

20200306419, Oct 1, 2020

Filed:

Apr 14, 2020

Appl. No.:

16/848814

Inventors:

- NEW ORLEANS LA, US
Vijay T. John - Destrehan LA, US
Ramesh Ayyala - New Orleans LA, US
Thiruselvam Ponnusamy - Beaverton OR, US

Assignee:

THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND - NEW ORLEANS LA

International Classification:

A61L 31/16
A61L 31/10
A61L 31/14
A61K 31/216
A61K 31/407
A61K 31/513
A61K 47/34
A61K 9/70
B29C 39/00
B29C 39/08
B29C 39/12
B29D 7/01

Abstract:

The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.

US Patent:

20180344905, Dec 6, 2018

Filed:

Aug 11, 2018

Appl. No.:

16/101413

Inventors:

- New Orleans LA, US
Vijay T. John - Destrehan LA, US
Ramesh Ayyala - New Orleans LA, US
Thiruselvam Ponnusamy - Beaverton OR, US

Assignee:

The Administrators of the Tulane Educational Fund - New Orleans LA

International Classification:

A61L 31/16
C08L 71/02
C08L 67/04
A61K 9/70
A61K 31/216
A61K 31/407
A61K 31/513
A61K 47/34
A61L 31/10
A61L 31/14
B29C 39/00
B29C 39/08
B29D 7/01
B29C 39/12
A61M 37/00
A61F 9/007
B29K 33/00

Abstract:

The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.

US Patent:

20150209487, Jul 30, 2015

Filed:

Feb 27, 2015

Appl. No.:

14/633282

Inventors:

- New Orleans LA, US
Vijay T. John - Destrehan LA, US
Ramesh Ayyala - New Orleans LA, US
Krzysztof Reiss - New Orleans LA, US

Assignee:

THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND - New Orleans LA

International Classification:

A61L 31/16
A61L 31/10
B29D 7/01
B29C 39/08
B29C 39/12
A61L 31/14
B29C 39/00

Abstract:

The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.