Peter James Maimonis

US Patent:

20060188889, Aug 24, 2006

Filed:

Nov 4, 2003

Appl. No.:

10/700439

Inventors:

Christopher Burgess - Westwood MA, US
Susan Myerow - Lexington MA, US
Arunthathi Thiagalingam - Lexington MA, US
Peter Maimonis - Westwood MA, US
Gary Molino - Norfolk MA, US
Lawrence Burgart - Rochester MN, US
Lisa Boardman - Rochester MN, US
Stephen Thibodeau - Rochester MN, US
Marcia Lewis - Cohasset MA, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.

US Patent:

20060275852, Dec 7, 2006

Filed:

Oct 27, 2005

Appl. No.:

11/262115

Inventors:

Jean Montagu - Brookline MA, US
Herman Deweerd - Bedford MA, US
Roger Dowd - Natick MA, US
Natalia Rodionova - Waltham MA, US
Peter Maimonis - Westwood MA, US
Nathan Tyburczy - Arlington MA, US

International Classification:

G01N 33/53
C12M 1/34

US Classification:

435007930, 435287200

Abstract:

Cassette () performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (), flowing over wide array () of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10to 5×10, are heated in region () preceding and including bubble removal system (). Analyte is introduced through compressed septum (). External actuations of displacement pumps () and valves (A, B, and C) produce flows in response to flow-front optical sensors (). Elastic sheet provides pump and valve diaphragms and resilient expansion of mixing volume (). Break-away cover portions are pistons. Heating is by conduction through cassette from external contact heater. Planar cassette body, when tilted from horizontal, enables upward flow from pumped storage () to reaction () to waste (), with buoyancy bubble removal before reaction. Reading of fluorescence is by external reader, employing calibration, control and reference features on capture surface. Extensive set of calibration features of differing intensities enables self-calibration.

US Patent:

20080194043, Aug 14, 2008

Filed:

Mar 21, 2008

Appl. No.:

12/052760

Inventors:

Jon H. ASTLE - Taunton MA, US
Christopher C. BURGESS - Westwood MA, US
Theodore J. CATINO - Attleboro MA, US
Poornima DWIVEDI - Alamo CA, US
Maryanne HUNTRESS - Attleboro MA, US
Karen Anne JOHNSON - Acton MA, US
Marcia E. LEWIS - Cohasset MA, US
Peter J. MAIMONIS - Westwood MA, US
Gary A. MOLINO - Norfolk MA, US
Susan H. MYEROW - Lexington MA, US
Arunthathi THIAGALINGAM - Lexington MA, US
Lisa Allyn BOARDMAN - Rochester MN, US
Lawrence J. BURGART - Rochester MN, US
Stephen N. THIBODEAU - Rochester MN, US

International Classification:

G01N 33/566

US Classification:

436501

Abstract:

The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1α or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1α or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1α or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.

US Patent:

20080233585, Sep 25, 2008

Filed:

Mar 13, 2008

Appl. No.:

12/047358

Inventors:

Christopher Burgess - Westwood MA, US
Susan Myerow - Lexington MA, US
Arunthathi Thiagalingam - Lexington MA, US
Peter Maimonis - Westwood MA, US
Gary Molino - Norfolk MA, US
Lawrence Burgart - Rochester MN, US
Lisa Allyn Boardman - Rochester MN, US
Stephen Thibodeau - Rochester MN, US
Marcia Lewis - Cohasset MA, US

International Classification:

C12Q 1/68
C07K 16/18
G01N 33/53

US Classification:

435 6, 530350, 5303879, 435 721

Abstract:

The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.

US Patent:

20110319279, Dec 29, 2011

Filed:

Sep 7, 2010

Appl. No.:

12/876883

Inventors:

Jean I. Montagu - Brookline MA, US
Herman Deweerd - Bedford MA, US
Roger Dowd - Natick MA, US
Natalia Rodionova - Waltham MA, US
Peter Maimonis - Westwood MA, US
Nathan Tyburczy - Arlington MA, US

Assignee:

AVANTRA BIOSCIENCES CORPORATION - Woburn MA

International Classification:

C40B 30/04
C40B 40/10

US Classification:

506 9, 506 18

Abstract:

Cassette () performs assays, e.g. multiplexed protein biomarker assays. Wide, bubble-free, slow flows are produced from liquids stored on cassette (), flowing over wide array () of ligand receptors on a capture surface. Flows of Reynolds Number less than about 1, preferably 1×10to 5×10, are heated in region () preceding and including bubble removal system (). Analyte is introduced through compressed septum (). External actuations of displacement pumps () and valves ( A, B, and C) produce flows in response to flow-front optical sensors (). Elastic sheet provides pump and valve diaphragms and resilient expansion of mixing volume (). Break-away cover portions are pistons. Heating is by conduction through cassette from external contact heater. Planar cassette body, when tilted from horizontal, enables upward flow from pumped storage () to reaction () to waste (), with buoyancy bubble removal before reaction. Reading of fluorescence is by external reader, employing calibration, control and reference features on capture surface. Extensive set of calibration features of differing intensities enables self-calibration.

US Patent:

20040157278, Aug 12, 2004

Filed:

Dec 12, 2003

Appl. No.:

10/734564

Inventors:

Jon Astle - Taunton MA, US
Christopher Burgess - Westwood MA, US
Theodore Catino - Attleboro MA, US
Poornima Dwivedi - Alamo CA, US
Maryanne Huntress - Attleboro MA, US
Karen Johnson - Acton MA, US
Marcia Lewis - Cohasset MA, US
Peter Maimonis - Westwood MA, US
Gary Molino - Norfolk MA, US
Susan Myerow - Lexington MA, US
Arunthathi Thiagalingam - Lexington MA, US
Lisa Boardman - Rochester MN, US
Lawrence Burgart - Rochester MN, US
Stephen Thibodeau - Rochester MN, US

International Classification:

G01N033/567
G01N033/574

US Classification:

435/007230

Abstract:

The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1 or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1 or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1 or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.

US Patent:

20190064179, Feb 28, 2019

Filed:

Oct 26, 2018

Appl. No.:

16/171777

Inventors:

- Eagan MN, US
Mary A. Antonysamy - Woodbury MN, US
Keith B. Gorden - Woodbury MN, US
Richard Walsh - Lino Lakes MN, US
Michael E. Danielson - St. Paul MN, US
Peter Maimonis - Westwood MA, US

International Classification:

G01N 33/68
C07K 16/14
A61K 39/00
G01N 33/53
G01N 33/569

Abstract:

This disclosure provides, in one aspect, a method for analyzing a sample from a subject for a biomarker that is indicative of the subject's immune response to β-glucan. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-β-glucan antibody compared to a reference standard, computing a Relative Antibody Unit (RAU) value for anti-β-glucan antibody in the sample, and identifying the subject as biomarker positive if the RAU value is greater than a predetermined RAU value for the biomarker anti-β-glucan antibody.

US Patent:

20180128836, May 10, 2018

Filed:

Dec 18, 2017

Appl. No.:

15/845421

Inventors:

- Eagan MN, US
Mary A. Antonysamy - Woodbury MN, US
Keith B. Gorden - Woodbury MN, US
Richard Walsh - Lino Lakes MN, US
Michael E. Danielson - St. Paul MN, US
Peter Maimonis - Westwood MA, US

International Classification:

G01N 33/68
G01N 33/53
C07K 16/14
A61K 39/00
G01N 33/569
C07K 16/16

Abstract:

This disclosure provides, in one aspect, a method for analyzing a sample from a subject for a biomarker that is indicative of the subject's immune response to β-glucan. Generally, the method includes obtaining a biological sample from a subject, analyzing the sample for a biomarker anti-β-glucan antibody compared to a reference standard, computing a Relative Antibody Unit (RAU) value for anti-β-glucan antibody in the sample, and identifying the subject as biomarker positive if the RAU value is greater than a predetermined RAU value for the biomarker anti-β-glucan antibody.