Peter R Guzzo

US Patent:

6596711, Jul 22, 2003

Filed:

Mar 1, 2001

Appl. No.:

09/786220

Inventors:

Kosrat Amin - Mölndal, SE
Thomas Elebring - Pixbo, SE
Peter Guzzo - Niskayuna NY
Thomas Olsson - Torslanda, SE
Marianne Swanson - Mölndal, SE
Sverker Von Unge - Fjärås, SE

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

A61K 3166

US Classification:

514114, 514120, 514129, 558169, 558178, 562 11

Abstract:

Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)methylphosphinic acid; ii) (S)-(3-amino-2-hydroxypropyl)methylphosphinic acid; iii) (R)-(3-amino-2-hydroxypropyl)methylphosphinic acid; iv) (3-amino-2-hydroxypropyl)difluoromethylphosphinic acid; and v) (3-amino-2-oxopropyl)methylphosphinic acid, having affinity to one or more GABA receptors, their pharmaceutically acceptable salts, solvates and stereoisomers, as well as a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy.

US Patent:

6841698, Jan 11, 2005

Filed:

Apr 4, 2003

Appl. No.:

10/406838

Inventors:

Thomas Elebring - Pixbo, SE
Peter Guzzo - Niskayuna NY, US
Marianne Swanson - Mölndal, SE
Sverker Von Unge - Fjär{dot over (a)}s, SE

Assignee:

AstraZeneca AB - Sodertalje

International Classification:

C07F 922
A61K 3166

US Classification:

562 11, 562 8, 514 75, 514114

Abstract:

Novel compounds of formula I, with the exception of.

US Patent:

6936611, Aug 30, 2005

Filed:

Jan 12, 2004

Appl. No.:

10/754923

Inventors:

John Walter Liebeschuetz - Bollington, GB
Christopher William Murray - Swavesey, GB
Stephen Clinton Young - Heaton Moor, GB
Nicholas Paul Camp - Bracknell, GB
Stuart Donald Jones - Macclesfield, GB
William Alexander Wylie - Carrickfergus, IE
John Joseph Masters - Fishers IN, US
Michael Robert Wiley - Indianapolis IN, US
Scott Martin Sheehan - Carmel IN, US
David Birenbaum Engel - Bloomington IN, US
Brian Morgan Watson - Carmel IN, US
Peter Robert Guzzo - Niskayuna NY, US
Michael John Mayer - Gulderland NY, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D401/12
C07D401/14
C07D403/12
A61K031/496
A61P009/10

US Classification:

51425214, 544121, 544238, 544281, 544360, 544363, 544367, 544364, 544370, 544373, 544357, 544374, 51425305, 51425306, 514 0, 51425309, 5142531, 51425402, 51425405, 51425403, 51425409, 5142541

Abstract:

Compounds of formula (I) in which R, X, Y, Cy, L and Lp(D)have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

US Patent:

6946467, Sep 20, 2005

Filed:

Dec 6, 2001

Appl. No.:

10/030187

Inventors:

John Walter Liebeschuetz - Bollington, GB
Christopher William Murray - Swavesey, GB
Stephen Clinton Young - Heaton Moor, GB
Nicholas Paul Camp - Bracknell, GB
Stuart Donald Jones - Macclesfield, GB
William Alexander Wylie - Carrickfergus, GB
John Joseph Masters - Fishers IN, US
Michael Robert Wiley - Indianapolis IN, US
Scott Martin Sheehan - Carmel IN, US
David Birenbaum Engel - Bloomington IN, US
Brian Morgan Watson - Carmel IN, US
Peter Robert Guzzo - Niskayuna NY, US
Michael John Mayer - Guiderland NY, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D401/14
A61K031/496
A61P007/02

US Classification:

51425309, 544364

Abstract:

The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.

US Patent:

7034176, Apr 25, 2006

Filed:

Dec 16, 2004

Appl. No.:

11/016543

Inventors:

Thomas Elebring - Pixbo, SE
Peter Guzzo - NIskayuna NY, US
Anders Holmén - Torslanda, SE
Thomas Olsson - Torslanda, SE
Marianne Swanson - Mölndal, SE
Sverker Von Unge - Färås, SE

Assignee:

Astrazeneca AB - Sodertalje

International Classification:

C07C 321/00
C07C 229/00
C07C 233/00
C07C 211/00
C07C 215/00

US Classification:

558151, 558169, 558170, 564197, 564336, 564355, 564503

Abstract:

Intermediates used in the preparation of compounds of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a solvate and a combination thereof,with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S,3R)-(3-amino-2-hydroxybutyl)phosphinic acid.

US Patent:

7351822, Apr 1, 2008

Filed:

Mar 18, 2004

Appl. No.:

10/803157

Inventors:

John Walter Liebeschuetz - Bollington, GB
Christopher William Murray - Swavesey, GB
Stephen Clinton Young - Heaton Moor, GB
Nicholas Paul Camp - Bracknell, GB
Stuart Donald Jones - Macclesfield, GB
William Alexander Wylie - Carrickfergus, GB
John Joseph Masters - Fishers IN, US
Michael Robert Wiley - Indianapolis IN, US
Scott Martin Sheehan - Carmel IN, US
David Birenbaum Engel - Bloomington IN, US
Brian Morgan Watson - Carmel IN, US
Peter Robert Guzzo - Niskayuna NY, US
Michael John Mayer - Gulderland NY, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D 401/12
C07D 401/14
A61K 31/496

US Classification:

544121, 544238, 544281, 544295, 544367, 544360, 544363, 544364, 544357, 544370, 544373, 544374

Abstract:

Compounds of formula (I).

US Patent:

7541357, Jun 2, 2009

Filed:

Jul 15, 2005

Appl. No.:

11/183066

Inventors:

Bruce F. Molino - Slingerlands NY, US
Shuang Liu - Schenectady NY, US
Peter R. Guzzo - Niskayuna NY, US
James P. Beck - Zionsville IN, US

Assignee:

AMR Technology, Inc. - Manchester Center VT

International Classification:

C07D 403/04
C07D 217/02
A61K 31/47

US Classification:

51423502, 514241, 51425204, 51425305, 514256, 514307, 544128, 544198, 544238, 544333, 544363, 546139

Abstract:

The compounds of the present invention are represented by the chemical structure found in Formula (I):.

US Patent:

7956050, Jun 7, 2011

Filed:

Jul 17, 2006

Appl. No.:

11/487884

Inventors:

Bruce F. Molino - Slingerlands NY, US
Shuang Liu - Schenectady NY, US
Aruna Sambandam - Delmar NY, US
Peter R. Guzzo - Niskayuna NY, US
Min Hu - Watervliet NY, US
Congxiang Zha - Schenectady NY, US
Kassoum Nacro - Albany NY, US
David D. Manning - Duanesburg NY, US
Matthew L. Isherwood - Delmar NY, US
Kristen N. Fleming - Clifton Park NY, US
Wenge Cui - Clifton Park NY, US
Richard E. Olson - Orange CT, US

Assignee:

Albany Molecular Research, Inc. - Albany NY

International Classification:

A61P 25/00
A61K 31/55
C07D 223/16

US Classification:

51421301, 540593

Abstract:

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II):.