Dr. Price graduated from the University of Colorado School of Medicine at Denver in 1975. He works in Englewood, CO and specializes in Emergency Medicine. Dr. Price is affiliated with Rose Medical Center and Swedish Medical Center.
This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory or degenerative joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers. The figure shows the elution position of substantially pure serum YKL-40 on a gel filtration column.
Assay For Ykl-40 As A Marker For Degradation Of Mammalian Connective Tissue Matrices
The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant levels of YKL-40 protein and/or YKL-40 peptide are present in a biological sample. The method can be used, for example, to identify the presence of inflammatory joint disease or degeneration of connective tissue in organs. Serum YKL-40 levels as detected and quantified by the invention method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.
Fetuin-Mgp-Mineral Complex In Serum Assayed To Determine Calcification Risk
The Regents of the University of California - Oakland CA
International Classification:
G01N 3320
US Classification:
436 79, 436 87
Abstract:
This invention provides methods of inhibiting calcification of a soft tissue (e. g. , an artery, a heart valve, an atherosclerotic plaque, a cancer, a kidney, a prostate, skin, muscle, cartilage, viscera, and heart muscle) in a mammal. These methods involve inhibiting osteoclastic bone resorption in said mammal (e. g. , a mammal diagnosed as having or at risk for a pathology characterized by calcification of a soft tissue). The inhibition is preferably by administration of a bisphosphonate to the mammal in a concentration sufficient to inhibit bone resorption without inhibiting bone mineralization. The methods of this invention can also be used to mitigate a symptom of atherosclerosis in a mammal. Such methods involve inhibiting osteoclastic bone resorption in the mammal. In preferred embodiment, the inhibiting is by administration of a bisphosphonate to the mammal in a concentration sufficient to inhibit bone resorption without inhibiting bone mineralization.
Assay For Ykl-40 As A Marker For Degradation Of Mammalian Connective Tissue Matrices
The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be used, for example, to identify the presence of inflammatory or degenerative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.
Ykl-40 As A Marker And Prognostic Indicator For Cancers
Paul A. Price - La Jolla CA, US Julia S. Johansen - Frederiksberg, DK
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 39/395
US Classification:
4241301
Abstract:
This invention provides methods for detecting cancers and for evaluating the prognosis of cancer patients. In particular, the methods of this invention utilize YKL-40 as a marker for the presence or absence of a cancer and for the prognosis (e. g. likelihood of recurrence) of a cancer. Elevated levels of YKL-40 are indicative of the presence of a cancer in undiagnosed subjects and indicate likely recurrence of the cancer in subjects diagnosed as having a cancer.
Richard Bonnichsen - Mahe, SC Paul Price - La Jolla CA, US
Assignee:
BIO-Y A/S
International Classification:
C07K 16/00
US Classification:
5303879, 5303871, 5303881, 5303888, 53038885
Abstract:
The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e. g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
This invention provides novel methods for making mineralized matrices. In certain embodiments methods are provided for forming a crystalline phase within a defined liquid volume. The methods can involve combining a crystallization inhibitor; a solution that would, in the absence of the inhibitor, form the crystalline phase; and a semi-permeable barrier that excludes the inhibitor but allows the solution containing the constituents of the crystalline phase to enter, whereby a crystalline phase is formed within the liquid volume.
Richard Bonnichsen - Victoria, SC Paul Price - La Jolla CA, US
International Classification:
C07K 16/40
US Classification:
5303879
Abstract:
The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
Jan 2011 to 2000 Administration Facility Support (EPA Region 6 Site)AllTech Protective LLC Dallas, TX Jul 2007 to Jan 2011 Security Administration
Education:
Ashworth College Norcross, GA 2009 to 2010 Associates Degree in Human Resource ManagementRowlett High School Rowlett, TX Jan 2007 Diploma
Skills:
Computer Skills: Proficient in using Microsoft Office XP, Microsoft Office [] MS Word, MS Access, MS Excel, MS FrontPage, MS Project, MS Visio, MS Site Server, Internet Explorer, Outlook, Outlook Express, PowerPoint, Adobe Photoshop and Lotus Notes.
Shincliffe, Durham Johnston, Brunel University, New College Durham
Paul Price
Work:
Workforce Strategy Group - Principle
Education:
East Tennessee State University
About:
Independent IT Sourcing Consultant (Workforce Strategy Group) and owner of The Utility Company, a franchised IT Managed Services Provider located in Central New Jersey... WorkforceSG.com FlemingtonNJ....
Tagline:
Husband, Father, Entrepreneur
Bragging Rights:
Surviving the teenage years...
Paul Price
Education:
Savannah College of Art and Design - Film and Television Production, Flower Mound High School
Paul Price
Education:
Virginia CollegeOn-line - Business Admin.
Relationship:
Single
Tagline:
Open-minded, down to earth, and not politically inclined.
Kern Elementary School East Detroit MI 1972-1976, Woodland Elementary School Eastpointe MI 1976-1977, Forest Park Elementary School Eastpointe MI 1977-1979, Kelly Junior High School East Detroit MI 1979-1981
Community:
Peter Hendrix, Christopher Mason
Youtube
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Hamma Lied
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Paul & Tina win the 1981 world championships with this awesome program...
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Take A Bow - Paul Price
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Paul and Price Little White Roses
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Ron Paul: Fed-Loving Senators Will Pay The Pr...
05/17/2010 - Ron Paul is America's leading voice for limited constitut...
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Ron Paul: Price Inflation Caused by Federal R...
Sign the Ron Paul 2012 Petition at www.RonPaul2012.... Please like, s...
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What the Price of Gold Is Telling Us by Ron P...
What the Price of Gold Is Telling Us by Ron Paul. Before the US House ...
Woodbridge, VA.Paul has strong experience in creating and implementing business solutions in key areas, including franchise development and management, managing multiple... Paul has strong experience in creating and implementing business solutions in key areas, including franchise development and management, managing multiple retail locations, and business to business sales and marketing. As Vice President for Children’s Orchard & Egismoz, a chain of retail/resale...