Paul J Flakoll

US Patent:

56283288, May 13, 1997

Filed:

Apr 25, 1995

Appl. No.:

8/428052

Inventors:

Steven L. Nissen - Ames IA
John A. Rathmacher - Nevada IA
Paul J. Flakoll - Old Hickory TN

Assignee:

Iowa State University Research Foundation - Ames IA
Vanderbilt University - Nashville TN

International Classification:

A61B 5103

US Classification:

128774

Abstract:

A method for determining muscle mass in a human subject useful for monitoring athletic conditioning, weight loss programs, nutritional deficiencies, and disease states which cause muscle wasting is provided comprising administration of a bolus dose of a metabolic marker for 3-methylhistidine, the use of a three-compartment model to describe data from blood samples collected periodically thereafter, and calculation of muscle mass as a function of specific values generated by the model.

US Patent:

53489799, Sep 20, 1994

Filed:

Dec 23, 1992

Appl. No.:

7/996187

Inventors:

Steven L. Nissen - Ames IA
Paul J. Flakoll - Old Hickory TN
Naji N. Abumrad - Old Field NY

Assignee:

Iowa State University Research Foundation Inc. - Ames IA
Vanderbilt University - Nashville TN

International Classification:

A61K 3119
A61K 31335
A23L 103

US Classification:

514557

Abstract:

Nitrogen retention in human subjects is promoted by administering. beta. -hydroxy-. beta. -methylbutyric acid (HMB). The amount of HMB administered is effective to conserve protein as determined by reduction in urinary nitrogen. The method can be used with patients having a negative nitrogen balance due to disease conditions, and also with normal elderly persons who are subject to protein loss. The HMB may be administered orally or by intravenous infusion.