Paul Creger from Southfield, MI

Carboxyalkylethers, Formulations, And Treatment Of Vascular Diseases
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US Patent:

57565449, May 26, 1998
Filed:

Feb 25, 1997
Appl. No.:

8/806582
Inventors:

Charles Larry Bisgaier - Ann Arbor MI
Paul Leroy Creger - Ann Arbor MI
Alan Robert Saltiel - Ann Arbor MI
Sherrie Rae Tafuri - Dexter MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 31225
US Classification:

514547
Abstract:

Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.

Carboxyalkylethers, Formulations, And Treatment Of Vascular Diseases
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US Patent:

56483872, Jul 15, 1997
Filed:

Mar 24, 1995
Appl. No.:

8/409780
Inventors:

Charles Larry Bisgaier - Ann Arbor MI
Paul Leroy Creger - Ann Arbor MI
Alan Robert Saltiel - Ann Arbor MI
Sherrie Rae Tafuri - Dexter MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 31225
US Classification:

514547
Abstract:

Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.

4-Oxy-Substituted Phenoxyalkyl Carboxylic Acid, Ester, And Alcohol Derivatives As Antihyper-Cholesterolemic And Antiatherosclerotic Agents
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US Patent:

51663988, Nov 24, 1992
Filed:

Jun 21, 1991
Appl. No.:

7/718736
Inventors:

Paul L. Creger - Ann Arbor MI
Assignee:

Warner-Lambert Co. - Mooris Plains NJ
International Classification:

C07C26100
US Classification:

560 32
Abstract:

Novel 4-oxy substituted phenoxyalkyl carboxylic acid, ester and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

Novel N-(Substituted-Phenyl)-5-(Substituted-2,5-Dimethylphenoxy)-2,2-Dimethylp Entanamides
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US Patent:

48823570, Nov 21, 1989
Filed:

Jul 15, 1988
Appl. No.:

7/219964
Inventors:

Paul L. Creger - Ann Arbor MI
Milton L. Hoefle - Ann Arbor MI
Ann Holmes - Dexter MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 31165
C07C10322
US Classification:

514622
Abstract:

Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylpen tan amides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

Novel N-(Substituted-Phenyl)-5-(Substituted-2,5-Dimethylphenoxy)-2,2-Dimethylp Entanamides
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US Patent:

49754564, Dec 4, 1990
Filed:

Jul 13, 1989
Appl. No.:

7/379457
Inventors:

Paul L. Creger - Ann Arbor MI
Milton L. Hoefle - Ann Arbor MI
Ann Holmes - Dexter MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 3136
C07D31766
US Classification:

514466
Abstract:

Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2- dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

Carboxyalkylethers, Formulations, And Treatment Of Vascular Diseases
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US Patent:

57836000, Jul 21, 1998
Filed:

Feb 25, 1997
Appl. No.:

8/806580
Inventors:

Charles Larry Bisgaier - Ann Arbor MI
Paul Leroy Creger - Ann Arbor MI
Alan Robert Saltiel - Ann Arbor MI
Sherrie Rae Tafuri - Dexter MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 31225
US Classification:

514547
Abstract:

Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.

Process For Mono-, Di-, Trisubstituted Acetic Acids
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US Patent:

50416405, Aug 20, 1991
Filed:

Sep 20, 1990
Appl. No.:

7/585741
Inventors:

Paul L. Creger - Ann Arbor MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

C07C 5968
C07C 5300
US Classification:

562471
Abstract:

An improved process for the preparation of mono-, di-, or trisubstituted acetic acids including 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid by a novel synthesis is described where a carboxylic acid is converted to a soluble metalated magnesium or zinc carboxylate containing a ligand and subsequent alkylation of this intermediate in the presence of an alkali amide to afford the desired product in two steps.

4-Amino Substituted Phenoxyalkyl Carboxylic Acid, Ester, And Alcohol Derivatives As Antihypercholesterolemic And Antiatherosclerotic Agents
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US Patent:

51771063, Jan 5, 1993
Filed:

Jun 21, 1991
Appl. No.:

7/718748
Inventors:

Paul L. Creger - Ann Arbor MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

A61K 31215
C07C 69612
US Classification:

514538
Abstract:

Novel 4-amino substituted phenoxyalkyl carboxylic acid, ester, and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

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Paul Creger