Parid Sava

US Patent:

20110293667, Dec 1, 2011

Filed:

Jan 14, 2011

Appl. No.:

13/007250

Inventors:

Dolores Baksh - North Easton MA,
Xianyan Wang - Acton MA,
Matthew Q. Wong - Watertown MA,
Lan Cao - Stoughton MA,
Parid Sava - Malden MA,
Thomas Bollenbach - Canton MA,
Esin Yesilalan - Boston MA,

International Classification:

A61K 35/12
A61K 35/44
A61K 35/50
A61K 35/34
C12P 21/00
A61K 9/00
A61P 19/04
A61P 19/08
A61P 21/00
A61K 35/28
A61K 35/32

US Classification:

424400, 424 937, 424 9321, 424520, 435 703, 435 691

Abstract:

Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be produced with multiple cell types that can all contribute to producing the extracellular matrix. Additionally or alternatively, one of the multiple cell types can be delivered to a site in the body via the endogenously produced extracellular matrix components to achieve various therapeutic benefits.