Orest T Macina

US Patent:

6380187, Apr 30, 2002

Filed:

Dec 5, 2000

Appl. No.:

09/730015

Inventors:

Dingwei Tim Yu - Easton PA 18040
Orest Taras Macina - Pittsburgh PA 15239
Ila Sircar - Clarks Summit PA 18411
Jagadish Chandra Sircar - Clarks Summit PA 18411
Christopher Mark Riviello - Old Forge PA 18518

International Classification:

C07D41710

US Classification:

5142278, 544 60

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

US Patent:

20010000178, Apr 5, 2001

Filed:

Dec 5, 2000

Appl. No.:

09/729750

Inventors:

Dingwei Yu - Easton PA, US
Orest Macina - Pittsburgh PA, US
Ila Sircar - Clarks Summit PA, US
Jagadish Sircar - Clarks Summit PA, US
Christopher Riviello - Old Forge PA, US

International Classification:

C 07D 4 1/04
A61K031/39

US Classification:

514/342000, 546/270400

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

US Patent:

20020002193, Jan 3, 2002

Filed:

Dec 5, 2000

Appl. No.:

09/729896

Inventors:

Dingwei Yu - Easton PA, US
Orest Macina - Pittsburgh PA, US
Ila Sircar - Clarks Summit PA, US
Jagadish Sircar - Clarks Summit PA, US
Christopher Riviello - Old Forge PA, US

International Classification:

A61K031/433
A61K031/4439
C07D285/06
C07D285/12
C07D285/08
C07D417/04

US Classification:

514/361000, 514/363000, 548/128000, 548/136000

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

US Patent:

62812173, Aug 28, 2001

Filed:

Dec 5, 2000

Appl. No.:

9/729902

Inventors:

Dingwei Tim Yu - Easton PA
Orest Taras Macina - Pittsburgh PA
Ila Sircar - Clarks Summit PA
Jagadish Chandra Sircar - Clarks Summit PA
Christopher Mark Riviello - Old Forge PA

International Classification:

A61K 31496
C07D41710

US Classification:

51425402

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

US Patent:

62778730, Aug 21, 2001

Filed:

Dec 5, 2000

Appl. No.:

9/729901

Inventors:

Dingwei Tim Yu - Easton PA
Orest Taras Macina - Pittsburgh PA
Ila Sircar - Clarks Summit PA
Jagadish Chandra Sircar - Clarks Summit PA
Christopher Mark Riviello - Old Forge PA

International Classification:

A61K 314245
C07D271107

US Classification:

514364

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

US Patent:

54362334, Jul 25, 1995

Filed:

Nov 19, 1993

Appl. No.:

8/154518

Inventors:

Sung J. Lee - Clarks Summit PA
Yoshitaka Konishi - Osaka, JP
Orest T. Macina - Clarks Summit PA
Kigen Kondo - Osaka, JP
Dingwei T. Yu - Easton PA

Assignee:

Ono Pharmaceutical Co., Ltd. - Osaka

International Classification:

C07D23995
C07D21516
A61K 31395
A61K 31505

US Classification:

514 63

Abstract:

The compounds of the formula: ##STR1## wherein R. sup. 1, Y, A, R. sup. 4, n, Z, CyB, R. sup. 3, and m are defined in the specification.

US Patent:

55256040, Jun 11, 1996

Filed:

Aug 24, 1994

Appl. No.:

8/295377

Inventors:

Sung J. Lee - Clarks Summit PA
Yoshitaka Konishi - Osaka, JP
Orest T. Macina - Clarks Summit PA
Kigen Kondo - Osaka, JP
Dingwei T. Yu - Easton PA
Tamara A. Miskowski - Clarks Summit PA

Assignee:

Ono Pharmaceutical Co., Ltd. - Osaka

International Classification:

C07D40104
C07D40106
C07D40112
A61K 31505

US Classification:

514256

Abstract:

A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene; Y is a bond, C1-4 alkylene, C1-4 alkyleneoxy, C1-4 alkoxyphenylene or phenyl(C1-4)alkylene; Z is a bond or vinylene; R1 is 4-15 membered heterocyclic ring containing one or two nitrogen atom; R2 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one or two of oxygen or one sulfur atom, (ii) C4-15 carbocyclic ring, (iii) C1-4 alkoxy, (iv) hydroxy(C1-4 alkoxy) or (v) hydroxy; R3 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one oxygen, one sulfur, or one nitrogen and one sulfur atom, (ii) C4-15 carbocyclic ring, (iii) formula: CH2. dbd. CH(X)-- wherein X is halogen. (iv) hydrogen.

US Patent:

61567760, Dec 5, 2000

Filed:

Mar 25, 1999

Appl. No.:

9/275863

Inventors:

Dingwei Tim Yu - Easton PA
Orest Taras Macina - Pittsburgh PA
Ila Sircar - Clarks Summit PA
Jagadish Chandra Sircar - Clarks Summit PA
Christopher Mark Riviello - Old Forge PA

International Classification:

A61K 31426
C07D27728

US Classification:

514365

Abstract:

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.