Dingwei Tim Yu - Easton PA 18040 Orest Taras Macina - Pittsburgh PA 15239 Ila Sircar - Clarks Summit PA 18411 Jagadish Chandra Sircar - Clarks Summit PA 18411 Christopher Mark Riviello - Old Forge PA 18518
International Classification:
C07D41710
US Classification:
5142278, 544 60
Abstract:
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Dingwei Yu - Easton PA, US Orest Macina - Pittsburgh PA, US Ila Sircar - Clarks Summit PA, US Jagadish Sircar - Clarks Summit PA, US Christopher Riviello - Old Forge PA, US
International Classification:
C 07D 4 1/04 A61K031/39
US Classification:
514/342000, 546/270400
Abstract:
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Dingwei Yu - Easton PA, US Orest Macina - Pittsburgh PA, US Ila Sircar - Clarks Summit PA, US Jagadish Sircar - Clarks Summit PA, US Christopher Riviello - Old Forge PA, US
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Dingwei Tim Yu - Easton PA Orest Taras Macina - Pittsburgh PA Ila Sircar - Clarks Summit PA Jagadish Chandra Sircar - Clarks Summit PA Christopher Mark Riviello - Old Forge PA
International Classification:
A61K 31496 C07D41710
US Classification:
51425402
Abstract:
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Dingwei Tim Yu - Easton PA Orest Taras Macina - Pittsburgh PA Ila Sircar - Clarks Summit PA Jagadish Chandra Sircar - Clarks Summit PA Christopher Mark Riviello - Old Forge PA
International Classification:
A61K 314245 C07D271107
US Classification:
514364
Abstract:
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
Sung J. Lee - Clarks Summit PA Yoshitaka Konishi - Osaka, JP Orest T. Macina - Clarks Summit PA Kigen Kondo - Osaka, JP Dingwei T. Yu - Easton PA Tamara A. Miskowski - Clarks Summit PA
Assignee:
Ono Pharmaceutical Co., Ltd. - Osaka
International Classification:
C07D40104 C07D40106 C07D40112 A61K 31505
US Classification:
514256
Abstract:
A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene; Y is a bond, C1-4 alkylene, C1-4 alkyleneoxy, C1-4 alkoxyphenylene or phenyl(C1-4)alkylene; Z is a bond or vinylene; R1 is 4-15 membered heterocyclic ring containing one or two nitrogen atom; R2 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one or two of oxygen or one sulfur atom, (ii) C4-15 carbocyclic ring, (iii) C1-4 alkoxy, (iv) hydroxy(C1-4 alkoxy) or (v) hydroxy; R3 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one oxygen, one sulfur, or one nitrogen and one sulfur atom, (ii) C4-15 carbocyclic ring, (iii) formula: CH2. dbd. CH(X)-- wherein X is halogen. (iv) hydrogen.
Diaryl Substituted Thiazoles Useful In The Treatment Of Fungal Infections
Dingwei Tim Yu - Easton PA Orest Taras Macina - Pittsburgh PA Ila Sircar - Clarks Summit PA Jagadish Chandra Sircar - Clarks Summit PA Christopher Mark Riviello - Old Forge PA
International Classification:
A61K 31426 C07D27728
US Classification:
514365
Abstract:
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.