Oliver W Press

US Patent:

7374778, May 20, 2008

Filed:

May 28, 2004

Appl. No.:

10/857626

Inventors:

Allan S. Hoffman - Seattle WA, US
Patrick Stayton - Seattle WA, US
Oliver W. Press - Seattle WA, US
Niren Murthy - Atlanta GA, US
Chantal Lackey Reed - Del Mar CA, US
Lawrence A. Crum - Bellevue WA, US
Pierre D. Mourad - Seattle WA, US
Tyrone M. Porter - Boston MA, US
David Tirrell - Pasadena CA, US

Assignee:

University of Washington - Seattle WA
University of Massachusetts - Boston MA

International Classification:

A61K 9/127
A61K 9/14
A61K 9/16
A61K 47/00

US Classification:

424450, 424489, 424501, 424 7809, 5147726

Abstract:

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered.

US Patent:

8003129, Aug 23, 2011

Filed:

Apr 18, 2008

Appl. No.:

12/105983

Inventors:

Allan S. Hoffman - Seattle WA, US
Patrick Stayton - Seattle WA, US
Oliver W. Press - Seattle WA, US
Niren Murthy - Atlanta GA, US
Chantal Lackey Reed - Del Mar CA, US
Lawrence A. Crum - Bellevue WA, US
Pierre D. Mourad - Seattle WA, US
Tyrone M. Porter - Boston MA, US
David Tirrell - Pasadena CA, US

Assignee:

University of Washington - Seattle WA
Univeristy of Massachusetts - Boston MA

International Classification:

A61K 9/14
A61K 9/16
A61K 47/00
A61K 9/127

US Classification:

424501, 424489, 424450, 5147726

Abstract:

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered.

US Patent:

20010007666, Jul 12, 2001

Filed:

Jan 5, 1999

Appl. No.:

09/226044

Inventors:

ALLAN S. HOFFMAN - SEATTLE WA, US
PATRICK STAYTON - SEATTLE WA, US
OLIVER W. PRESS - SEATTLE WA, US
DAVID TIRRELL - PASADENA CA, US
NIREN MURTHY - SEATTLE WA, US
CHANTAL LACKEY - SEATTLE WA, US
LAWRENCE A. CRUM - ISSAQUAH WA, US
PIERRE D. MOURAD - SEATTLE WA, US
TYRONE M. PORTER - SEATTLE WA, US

International Classification:

A61K009/00

US Classification:

424/400000

Abstract:

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

US Patent:

20110288238, Nov 24, 2011

Filed:

Jul 14, 2011

Appl. No.:

13/182756

Inventors:

Allan S. Hoffman - Seattle WA, US
Patrick Stayton - Seattle WA, US
Oliver W. Press - Seattle WA, US
Niren Murthy - Atlanta GA, US
Chantal Lackey Reed - Del Mar CA, US
Lawrence A. Crum - Bellevue WA, US
Pierre D. Mourad - Seattle WA, US
Tyrone M. Porter - Boston MA, US
David Tirrell - Pasadena CA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS - Boston MA
UNIVERSITY OF WASHINGTON - Seattle WA

International Classification:

C08F 220/06
C08F 265/02
C08F 299/00

US Classification:

525299, 525301, 5253297

Abstract:

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents.

US Patent:

20130309171, Nov 21, 2013

Filed:

Apr 29, 2013

Appl. No.:

13/872827

Inventors:

Oliver W. Press - Seattle WA, US
Jonathan Whitney Gunn - Seattle WA, US
Steven I. Park - Mountlake Terrace WA, US

Assignee:

University of Washington through its Center for Commercialization - Seattle WA

International Classification:

A61K 47/48
A61K 48/00
A61K 49/00

US Classification:

424 91, 4241781, 435 71

Abstract:

Nanoparticle system and method for labeling, detecting, and treating biological particles. In the method, targeting functionality (fusion protein) and therapeutic/imaging modalities (nanoparticle) are separated.

US Patent:

20140219950, Aug 7, 2014

Filed:

Feb 7, 2014

Appl. No.:

14/175891

Inventors:

- Boston MA, US
- Seattle WA, US
Oliver W. Press - Seattle WA, US
Niren Murthy - Atlanta GA, US
Chantal Lackey Reed - Del Mar CA, US
Lawrence A. Crum - Bellevue WA, US
Pierre D. Mourad - Seattle WA, US
Tyrone M. Porter - Boston MA, US
David Tirrell - Pasadena CA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS - Boston MA
UNIVERSITY OF WASHINGTON - Seattle WA

International Classification:

A61K 47/48

US Classification:

424 7829, 525 541, 424 7827, 435375

Abstract:

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.