Nicusor Vasile Iftimia

US Patent:

7567349, Jul 28, 2009

Filed:

Mar 31, 2004

Appl. No.:

10/551735

Inventors:

Guillermo J. Tearney - Cambridge MA, US
Nicusor Iftimia - Quincy MA, US
Brett Eugene Bouma - Quincy MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01B 9/02

US Classification:

356479, 356497

Abstract:

Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation.

US Patent:

7648242, Jan 19, 2010

Filed:

May 1, 2007

Appl. No.:

11/799315

Inventors:

R. Daniel Ferguson - Melrose MA, US
Daniel X. Hammer - Bedford NH, US
Nicusor V. Iftimia - Chelmsford MA, US
Chad Bigelow - Cambridge MA, US

Assignee:

Physical Sciences, Inc. - Andover MA

International Classification:

A61B 3/10

US Classification:

351221, 351205, 25036304, 382131

Abstract:

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

US Patent:

7758189, Jul 20, 2010

Filed:

Apr 24, 2007

Appl. No.:

11/789800

Inventors:

Daniel X. Hammer - Bedford NH, US
R. Daniel Ferguson - Melrose MA, US
Nicusor V. Iftimia - Chelmsford MA, US
Teoman E. Ustun - Malden MA, US

Assignee:

Physical Sciences, Inc. - Andover MA

International Classification:

A61B 3/10

US Classification:

351206, 351200

Abstract:

A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam relative to the reference feature to correct for the motion of the object. A third module detects a distortion of the object and compensates for the distortion.

US Patent:

7761139, Jul 20, 2010

Filed:

Jan 26, 2004

Appl. No.:

10/765430

Inventors:

Guillermo J. Tearney - Cambridge MA, US
Milen Stefanov Shishkov - Watertown MA, US
Nicusor V. Iftimia - North Chelmsford MA, US
Brett E. Bouma - Quincy MA, US
Martha Pitman - Swampscott MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61B 5/00

US Classification:

600473, 600476

Abstract:

An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

US Patent:

7866821, Jan 11, 2011

Filed:

Dec 3, 2009

Appl. No.:

12/630358

Inventors:

R. Daniel Ferguson - Melrose MA, US
Daniel X. Hammer - Bedford NH, US
Nicusor V. Iftimia - Chelmsford MA, US
Chad Bigelow - Cambridge MA, US

Assignee:

Physical Sciences, Inc. - Andover MA

International Classification:

A61B 3/10

US Classification:

351221, 351205, 25036304, 382131

Abstract:

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser opthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

US Patent:

7896496, Mar 1, 2011

Filed:

Jun 17, 2010

Appl. No.:

12/817789

Inventors:

Daniel X. Hammer - Bedford NH, US
R. Daniel Ferguson - Melrose MA, US
Nicusor V. Iftimia - Chelmsford MA, US
Teoman E. Ustun - Malden MA, US

Assignee:

Physical Sciences, Inc. - Andover MA

International Classification:

A61B 3/14

US Classification:

351206, 351200

Abstract:

A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam relative to the reference feature to correct for the motion of the object. A third module detects a distortion of the object and compensates for the distortion.

US Patent:

8033665, Oct 11, 2011

Filed:

Dec 9, 2010

Appl. No.:

12/964518

Inventors:

R. Daniel Ferguson - Melrose MA, US
Daniel X. Hammer - Bedford NH, US
Nicusor V. Iftimia - Chelmsford MA, US
Chad Bigelow - Cambridge MA, US

Assignee:

Physical Sciences, Inc. - Andover MA

International Classification:

A61B 3/10

US Classification:

351221, 351205, 25036304, 382131

Abstract:

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

US Patent:

8145018, Mar 27, 2012

Filed:

Jan 17, 2007

Appl. No.:

11/623852

Inventors:

Milen Shishkov - Watertown MA, US
Guillermo J. Tearney - Cambridge MA, US
Brett Eugene Bouma - Quincy MA, US
Dvir Yelin - Brookline MA, US
Nicusor Iftimia - North Chelmsford MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G02B 6/32
G02B 6/34
G02B 6/06

US Classification:

385 33, 385 31, 385 34, 385 36, 385 37, 385 38, 385 39, 385 49, 385115, 385116, 385117, 385119

Abstract:

Exemplary apparatus for obtaining information for a structure can be provided. For example, first optical fiber arrangement(s) can be provided which transceives at least one first electro-magnetic radiation, and can include at least one fiber. Second focusing arrangement(s) can be provided in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation. Third dispersive arrangement(s) can receive a particular radiation which is the first electro-magnetic radiation and/or the focused electro-magnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement.