Nicola J Mason

US Patent:

20110158997, Jun 30, 2011

Filed:

Apr 8, 2009

Appl. No.:

12/936981

Inventors:

Nicola Mason - Philadelphia PA, US

International Classification:

A61K 39/395
C12P 19/34
C40B 40/08
C40B 30/04
C07H 21/00
C07K 16/00
C12N 5/09
G01N 33/574
C12Q 1/70
A61P 35/00
A61P 35/04
A61P 31/12
A61P 31/20
A61P 29/00
A61P 31/04
A61P 31/10
A61P 33/00
A61P 37/04

US Classification:

4241351, 435 912, 506 17, 506 9, 4241781, 536 2353, 5303873, 435375, 435 723, 435 5

Abstract:

The invention is generally directed to antibody variable domains or antibodies, libraries of antibody variable domains or antibodies, methods of making said antibodies and libraries, and methods of treatment comprising administering the generated antibody variable domains or antibodies. Specifically, the invention is directed to novel primer nucleotide sequences that are used to amplify all rearranged sequences of canine variable heavy (VH) and variable light (VL) immunoglobulin chains that have been used in naturally occurring antibody responses. These novel sequences contain canine framework regions and complementarity determining regions which may be used to canine-ize antibodies. Further, these sequences are useful for the identification and targeting of viral and bacterial pathogens, and tumor-associated antigens.

US Patent:

20160361401, Dec 15, 2016

Filed:

Feb 25, 2015

Appl. No.:

15/121421

Inventors:

- Princeton NJ, US
- Philadephia PA, US
Paulo C. Maciag - Long Grove IL, US
Yvonne Paterson - Philadelphia PA, US
Nicola Mason - Philadelphia PA, US
Matthew Seavey - Secane PA, US

International Classification:

A61K 39/00
C07K 14/195
C12N 9/90
C12N 9/12
C12N 1/36
C12N 1/20
C07K 14/82
C12N 15/74

Abstract:

This invention provides compositions and methods for treating and vaccinating against a HER2/neu antigen-expressing tumor and inducing an immune response against the same in a subject.

US Patent:

20150366955, Dec 24, 2015

Filed:

Feb 25, 2014

Appl. No.:

14/189008

Inventors:

- Princeton NJ, US
- Philadelphia PA, US
Paulo C. Maciag - Long Grove IL, US
Yvonne Paterson - Philadelphia PA, US
Nicola Mason - Philadelphia PA, US
Matthew M. Seavey - Secane PA, US

International Classification:

A61K 39/00

Abstract:

This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.

US Patent:

20150297702, Oct 22, 2015

Filed:

Jul 1, 2015

Appl. No.:

14/788936

Inventors:

- Princeton NJ, US
- Philadelphia PA, US
PAULO C. MACIAG - LONG GROVE IL, US
YVONNE PATERSON - PHILADELPHIA PA, US
MATTHEW SEAVEY - SECANE PA, US
NICOLA MASON - PHILADELPHIA PA, US

International Classification:

A61K 39/02
A61K 35/742

Abstract:

This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a human subject.