Neal E. Fearnot - West Lafayette IN Michael C. Hiles - Lafayette IN
Assignee:
Med Institute, Inc. - West Lafayette IN Cook Biotech, Inc. - West Lafayette IN
International Classification:
A61F 236
US Classification:
623 2372, 623 144, 424551
Abstract:
An easy-to-produce and mechanically strong tube of an implantable graft prosthesis has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the graft prosthesis generally involves wrapping multiple sheets of a purified, collagen-based matrix structure around a mandrel, compressing and drying the tissue on the mandrel before removing the construct for eventual use.
Charles F. Babbs - West Lafayette IN Neal F. Fearnot - West Lafayette IN Stephen F. Badylak - West Lafayette IN Leslie A Geddes - West Lafayette IN Michael C. Hiles - Lafayette IN Joe D. Bourland - West Lafayette IN
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61F 206
US Classification:
623 113
Abstract:
A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent ( ) covered with submucosal tissue ( ) wherein the stent ( ) is formed for receiving the distal end of a catheter ( ) having an inflatable balloon ( ).
Marc G. Apple - Fort Wayne IN 47906 Brian L. Bates - Bloomington IN John A. DeFord - Bloomington IN Neal E. Fearnot - West Lafayette IN James D. Purdy - Lafayette IN Joseph P. Lane - Bloomington IN Delbert C. Miller - Bloomington IN Gregory A. Frankland - Unionville IN
Assignee:
Marc G. Apple - Ft. Wayne IN
International Classification:
A61N 0500
US Classification:
600 3
Abstract:
A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. A radiotherapy source vial ( ) includes a fluid container ( ) of radioactive fluid with a seal ( ) disposed about the container. Seal ( ) is moveable with respect to container ( ) to change the contained volume therein. A radioactive fluid transport site ( ) is in communication with the contained volume and with an exterior ( ) of the container ( ), and may include a septum ( ) or a valve ( ). An engagement mechanism ( ) is connectable to an external control mechanism ( ) whereby the contained volume in the radioactive fluid container can be decreased and increased by actuation of the external control mechanism.
Neal E. Fearnot - West Lafayette IN Brian D. Choules - West Lafayette IN Matthew S. Waninger - Frankfort IN Michael P. DeBruyne - Bloomington IN
Assignee:
MED Institute, Inc. - West Lafayette IN Cook Incorporated - Bloomington IN
International Classification:
A61F 206
US Classification:
623 114, 623 113, 623 115
Abstract:
An expandable stent prosthesis is disclosed in which the apices of the bends located at at least one end of the stent are individually twisted at an angle to the circumference of the stent to form a fan blade-like arrangement when viewed from that end. The fan blade-like arrangement allows the stent to expand from the compressed condition during deployment such that likelihood of a strut or bend of the stent become entangled with a barb or adjacent strut or bend, is reduced. In one embodiment of the invention, the fan blade-like arrangement results from plastically deforming the individual apices, while in another embodiment, the apices are twisted into the fan blade-like arrangement during the loading process, such as by use of a suture thread to pull the apices into alignment.
Brian L. Bates - Bloomington IN Neal E. Fearnot - West Lafayette IN Thomas G. Kozma - West Lafayette IN Thomas A. Osborne - Bloomington IN Anthony O. Ragheb - West Lafayette IN Joseph W. Roberts - St. Paul MN
Assignee:
Cook Incorporated - Bloomington IN MED Institute Inc. - West Lafayette IN
A silver implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer of a bioactive material posited on one surface of structure ; and at least one porous layer posited over the bioactive material layer posited on one surface of structure and the bioactive-material-free surface. Also included is a layer or impregnation of silver. Preferably, the structure is a coronary stent. The porous layer is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.
Anthony O. Ragheb - West Lafayette IN Brian L. Bates - Bloomington IN Neal E. Fearnot - West Lafayette IN Thomas G. Kozma - Lafayette IN
Assignee:
Cook Incorporated - Bloomington IN Med Institute Inc. - West Lafayette IN
International Classification:
A61M 532
US Classification:
604265, 623623, 623 115, 623 136, 623 142
Abstract:
A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer wherein the coating layer provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer can be posited over the bioactive material layer wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure is a coronary stent. The porous layer includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
Brian L. Bates - Bloomington IN Dale T. Berry - West Lafayette IN Neal E. Fearnot - West Lafayette IN Coy M. Herald - West Lafayette IN Palle M. Hansen - Bjaeverskov, DK Jesper Thyregod - Roskilde, DK
Assignee:
Cook Incorporated - Bloomington IN William Cook Europe ApS - Bjaeverskov MED Institute Incorporated - West Lafayette IN
International Classification:
A61F 206
US Classification:
623 115
Abstract:
A stent ( ) formed from cannula and having flexible segments ( ) and high hoop strength segments ( ) alternating therealong. Axial tie bars ( ) interconnect the segments; minimal length reduction would occur upon expansion. In the high hoop strength segment ( ), struts ( ) are initially parallel in the unexpanded strut condition, while in the flexible segment ( ), struts ( ) extend from a respective bight ( ) to converge at distal ends when unexpanded. In one embodiment, certain adjacent struts ( ) of the hoop segment are spaced apart by a large gap ( ) while others are spaced apart by a small gap ( ). In another embodiment all the struts ( ) of the hoop segment are spaced apart uniformly from each other (or from an axial tie bar) by a small gap ( ), resulting in minimizing the occurrence of fatigue of high-stress sites upon expansion/contraction cycles from continuous pulsatile events.
Anthony O. Ragheb - West Lafayette IN Brian L. Bates - Bloomington IN Neal E. Fearnot - West Lafayette IN Thomas G. Kozma - West Lafayette IN Anthony H. Gershlick - Leicestershire, GB
Assignee:
Cook Incorporated - Bloomington IN MED Institute, Inc. - West Lafayette IN
International Classification:
A61F 206
US Classification:
623 11, 623 146
Abstract:
A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer wherein the coating layer provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer can be posited over the bioactive material layer wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure is a coronary stent. The porous layer includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
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