Narasimha M Vemuri from 22 Dally Rd, Flemington, NJ 08822, age 60, Phone: 908-782-0489

Stable Non-Hygroscopic Crystalline Form Of N-[N-[N-(4-(Piperidin-4-Yl)Butanoyl)-N-Ethylglycyl]Aspartyl]-L--Cyclohexyl Alanine Amide, Intermediates Thereof, And Preparation Thereof And Of Antithrombotic Azacycloalkylalkanoyl Peptides And Pseudopeptides
view source
US Patent:

6753409, Jun 22, 2004
Filed:

Aug 15, 2000
Appl. No.:

09/639634
Inventors:

Zofia J. Chrzan - Sellersville PA
James J. Mencel - Lansdale PA
Vincent Windisch - Green Lane PA
Rick G. Woodward - Harleysville PA
Diane C. Salazar - late of Wayne PA
Narasimha M. Vemuri - Phoenixville PA
Anthony J. Gardetto - Oley PA
Matthew R. Powers - Barto PA
Gregory G. Kubiak - Wilmington DE
Robert C. Liu - Walnut Creek CA
Benoit J. Vanasse - Collegeville PA
James P. Sherbine - Voorhees NJ
Walter Rodriguez - Douglasville PA
Adam W. Sledeski - Collegeville PA
Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ
International Classification:

C07K 508
US Classification:

530331, 530333, 514 19
Abstract:

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)--cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E , E , G, R, m, n, and p are as defined herein.

Stable Non-Hygroscopic Crystalline Form Of N-[N-[N-4-(Piperidin-4-Yl)Butanoyl)-N-Ethylglycyl] Aspartyl]-L-.Beta.-Cyclohexyl Alanine Amide
view source
US Patent:

61535885, Nov 28, 2000
Filed:

Feb 18, 1999
Appl. No.:

9/251030
Inventors:

Zofia J. Chrzan - Sellersville PA
James J. Mencel - Lansdale PA
Vincent Windisch - Green Lane PA
Rick G. Woodward - Harleysville PA
Diane C. Salazar - late of Wayne PA
Narasimha M. Vemuri - Phoenixville PA
Anthony J. Gardetto - Oley PA
Matthew R. Powers - Barto PA
Gregory G. Kubiak - Wilmington DE
Robert C. Liu - Walnut Creek CA
Benoit J. Vanasse - Collegeville PA
James P. Sherbine - Voorhees NJ
Walter Rodriguez - Douglasville PA
Adam W. Sledeski - Collegeville PA
Assignee:

Aventis Pharmaceuticals Products Inc. - Collegeville PA
International Classification:

A61K 3806
C07K 500
US Classification:

514 18
Abstract:

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-. beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E. sup. 1, E. sup. 2, G, R, m, n, and p are as defined herein.

Narasimha M Vemuri