Sean Patrick Hollinshead - Durham NC Philip Floyd Hughes - Chapel Hill NC Jose Serafin Mendoza - Durham NC Joseph Wendell Wilson - Durham NC Bret Eugene Huff - Mooresville IN Charles Howard Mitch - Columbus IN Michael Alexander Staszak - Indianapolis IN John Stanley Ward - Indianapolis IN
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.
Sean P. Hollinshead - Durham NC Michael A. Staszak - Indianapolis IN John S. Ward - Indianapolis IN Joseph W. Wilson - Durham NC Bret E. Huff - Mooresville IN Philip F. Hughes - Chapel Hill NC Jose S. Mendoza - Durham NC Charles H. Mitch - Columbus IN
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.
John Robert Rizzo - Indianapolis IN Michael Alexander Staszak - Indianapolis IN Tony Yantao Zhang - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D21140
US Classification:
546192, 546216, 546219
Abstract:
The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.
Sung Yong S. Cho - Indianapolis IN James D. Copp - Greenwood IN Francis O. Ginah - Indianapolis IN Guy J. Hansen - Indianapolis IN Philip A. Hipskind - New Palestine IN Bret E. Huff - Mooresville IN Michael J. Martinelli - Indianapolis IN Michael A. Staszak - Indianapolis IN Roger W. Tharp-Taylor - Noblesville IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31445 C07D40114
US Classification:
514316
Abstract:
This invention provides novel compound of the formula ##STR1## which is neurokinin receptor antagonist.
Robin D. G. Cooper - Indianapolis IN Bret E. Huff - Mooresville IN Thalia I. Nicas - Indianapolis IN John T. Quatroche - Indianapolis IN Michael J. Rodriguez - Indianapolis IN Nancy J. Snyder - Charlottesville IN Michael A. Staszak - Indianapolis IN Richard C. Thompson - Frankfort IN Stephen C. Wilkie - Indianapolis IN Mark J. Zweifel - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07K 750 C07K 900 A61K 3702
US Classification:
514 8
Abstract:
The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity aginst a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.
Robin D. G. Cooper - Indianapolis IN Bret E. Huff - Mooresville IN Thalia I. Nicas - Indianapolis IN John T. Quatroche - Indianapolis IN Michael J. Rodriguez - Indianapolis IN Nancy J. Snyder - Charlottesville IN Michael A. Staszak - Indianapolis IN Richard C. Thompson - Frankfort IN Stephen C. Wilkie - Indianapolis IN Mark J. Zweifel - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 3812 A61K 3814 C07K 754 C07K 900
US Classification:
514 11
Abstract:
The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity against a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.
Christopher W. Doecke - Greenwood IN Jeffrey N. Levy - Lafayette IN Wayne D. Luke - West Lafayette IN Michael A. Staszak - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D205085 C07B 5700
US Classification:
540200
Abstract:
Enantiomerically pure. beta. -lactam intermediates of the formula (I) ##STR1## are isolated from a haloalkane solvent through precipitation with methyl-t-butyl ether or methanol. The products thus obtained are key intermediates in the synthesis of antibiotic aagents. The process is appropriate for large scale production.