Kevin J. Yarema - Woodstock MD, US Udayanath Aich - Baltimore MD, US Christopher Thomas Campbell - Baltimore MD, US Srinivasa-Gopalan Sampathkumar - New Delhi, IN Sean S. Choi - Baltimore MD, US Michael Adam Meledeo - Odenton MD, US Christopher Weier - Baltimore MD, US
Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
- Beverly MA, US - JBSA Fort Sam Houston TX, US Andrew Peter Cap - Hollywood Park TX, US Michael Adam Meledeo - San Antonio TX, US
International Classification:
G01N 33/86 A01N 1/02 A61K 35/16
Abstract:
The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).
Hybrid Scfa-Hydroxyl-Derivatized Monosaccharides, Methods Of Synthesis, And Methods Of Treating Disorders
- Baltimore MD, US Udayanath Aich - Cambridge MA, US Christopher T. Campbell - Baltimore MD, US Srinivasa-Gopalan Sampathkumar - New Delhi, IN Sean S. Choi - Columbia MD, US Michael A. Meledeo - San Antonio TX, US Christopher Weier - Baltimore MD, US
Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Hybrid Scfa-Hydroxyl-Derivatized Monosaccharides, Methods Of Synthesis, And Methods Of Treating Disorders
- Baltimore MD, US Udayanath Aich - Cambridge MA, US Christopher T. Campbell - Baltimore MD, US Srinivasa-Gopalan Sampathkumar - New Delhi, IN Sean S. Choi - Columbia MD, US Michael A. Meledeo - San Antonio TX, US Christopher Weier - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C07H 13/04
US Classification:
435 691, 536 172, 435375
Abstract:
Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Us Army May 2014 - Dec 2015
Orise Research Fellow
Us Army May 2014 - Dec 2015
Research Scientist
Us Army Jul 2012 - Apr 2014
Staff Scientist
Us Army Jan 2010 - Jul 2012
Nrc Postdoctoral Fellow
Johns Hopkins School of Medicine Aug 2002 - Nov 2009
Ph.d Graduate
Education:
The Johns Hopkins University School of Medicine 2002 - 2009
Doctorates, Doctor of Philosophy, Biomedical Engineering, Philosophy