Michael Adam Meledeo

US Patent:

20110206734, Aug 25, 2011

Filed:

Aug 7, 2008

Appl. No.:

12/671994

Inventors:

Kevin J. Yarema - Woodstock MD, US
Udayanath Aich - Baltimore MD, US
Christopher Thomas Campbell - Baltimore MD, US
Srinivasa-Gopalan Sampathkumar - New Delhi, IN
Sean S. Choi - Baltimore MD, US
Michael Adam Meledeo - Odenton MD, US
Christopher Weier - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 39/00
C07H 15/04
A61K 31/7028
C07H 13/04
A61K 31/7024
A61P 35/00
C12N 5/071

US Classification:

4242771, 536 182, 514 25, 536 53, 514 62, 435375

Abstract:

Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

US Patent:

20170370952, Dec 28, 2017

Filed:

Apr 7, 2017

Appl. No.:

15/481573

Inventors:

- Beverly MA, US
- JBSA Fort Sam Houston TX, US
Andrew Peter Cap - Hollywood Park TX, US
Michael Adam Meledeo - San Antonio TX, US

International Classification:

G01N 33/86
A01N 1/02
A61K 35/16

Abstract:

The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).

US Patent:

20160151400, Jun 2, 2016

Filed:

Jun 30, 2015

Appl. No.:

14/755539

Inventors:

- Baltimore MD, US
Udayanath Aich - Cambridge MA, US
Christopher T. Campbell - Baltimore MD, US
Srinivasa-Gopalan Sampathkumar - New Delhi, IN
Sean S. Choi - Columbia MD, US
Michael A. Meledeo - San Antonio TX, US
Christopher Weier - Baltimore MD, US

International Classification:

A61K 31/7008
A61K 31/7028
G01N 33/50
C07H 13/04
A61K 31/7012
A61K 45/06
C07H 15/04
C07H 5/06

Abstract:

Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

US Patent:

20140220630, Aug 7, 2014

Filed:

Apr 7, 2014

Appl. No.:

14/246809

Inventors:

- Baltimore MD, US
Udayanath Aich - Cambridge MA, US
Christopher T. Campbell - Baltimore MD, US
Srinivasa-Gopalan Sampathkumar - New Delhi, IN
Sean S. Choi - Columbia MD, US
Michael A. Meledeo - San Antonio TX, US
Christopher Weier - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

C07H 13/04

US Classification:

435 691, 536 172, 435375

Abstract:

Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.