RXi Pharmaceuticals Corporation Biotechnology · A Development Stage Company Engaged In Biopharmaceutical Preparations · Biopharmaceutical Preparations · Mfg Pharmaceutical Preparations
257 Simarano Dr SUITE 101, Marlborough, MA 01752 1500 W Park Dr, Westboro, MA 01581 60 Prescott St, Worcester, MA 01605 508-767-3861
Michael P. Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson L. Guilherme - Shrewsbury MA, US Andrew D. Cherniack - Shrewsbury MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
A61K 48/00
US Classification:
514 44, 536 245, 536 2431, 536 241
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e. g. , diabetes), treating obesity, increasing metabolism (e. g. , fatty acid metabolism), and increasing brown fat.
Glucose-Transport Related Genes, Polypeptides, And Methods Of Use Thereof
Michael P. Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson L. Guilherme - Shrewsbury MA, US Andrew D. Cherniack - Shrewsbury MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
A61K 48/00
US Classification:
514 44, 536 245, 536 241, 536 2431
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e. g. , diabetes), treating obesity, increasing metabolism (e. g. , fatty acid metabolism), and increasing brown fat.
Increasing Glucose Transport And Insulin-Stimulated Glucose Uptake
Methods and compositions for delivering agents (e. g. , gene silencing agents) and molecules to cells using yeast cell wall particles are presented herein. Embodiments of the invention are particularly useful for the delivery of nucleic acids (e. g. , siRNAs) to cells.
Michael P. Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson L. Guilherme - Shrewsbury MA, US Andrew D. Cherniack - Worcester MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
C07H 21/04
US Classification:
536 245, 536 241, 536 2431, 514 44
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e. g. , diabetes), treating obesity, increasing metabolism (e. g. , fatty acid metabolism), and increasing brown fat.
Michael Czech - Westborough MA, US Andrew Cherniack - Worcester MA, US Adilson Guilherme - Shrewsbury MA, US
International Classification:
C12Q001/68 C12M001/34
US Classification:
435/006000, 435/287200
Abstract:
Nucleotide sequences and amino acid sequences from nucleic acids and proteins involved in glucose transport are disclosed. The sequences are useful for producing DNA arrays that can be used for the diagnosis of, predictive testing for, and development of treatments for disorders involving glucose transport such as type II diabetes.
Michael Czech - Westborough MA, US Qiong Zhou - Shrewsbury MA, US Zhen Jiang - Shrewsbury MA, US
Assignee:
UNIVERSITY OF MASSACHUSETTS - Worcester MA
International Classification:
C12N015/87
US Classification:
435459000
Abstract:
In general, it has been difficult to introduce nucleic acid sequences into adipocytes. Methods are described for introducing nucleic acids such as siRNAs into adipocytes, including the introduction of sequences targeting Akt1, Akt2 and Myo1. Methods for identifying genes involved in glucose transport and for identifying insulin response modulators are described. Therapeutic methods are also provided.
St. Augustine Elementary School St. Cloud MN 1997-2001
Community:
Colane Recker, Robert Keeney, Sandra Longwell, John Gohl, Jennifer Umerski, Michael Dale, Leah Wienhold, Mandy Becker, Ashley Carlson, Thomas Pino, Mary Peka