Michael J Colman

US Patent:

7074333, Jul 11, 2006

Filed:

Jan 19, 2001

Appl. No.:

09/766161

Inventors:

Michael S. Colman - Beverly MA, US

Assignee:

Millipore Corporation - Billerica MA

International Classification:

B01D 61/14
C07H 21/00

US Classification:

210650, 210639, 210644, 210651, 210767, 435 6, 435 912, 536 231, 536 254

Abstract:

A method of recovery of DNA fragments using ultrafiltration. The method of the present invention relates to the separation and/or fractionation of double stranded linear nucleic acids using continuous pressure differential ultrafiltration to achieve improved recovery of small PCR products. In one embodiment, dilution of sample such as small PCR products is carried out prior to purification by ultrafiltration. Subsequent filtration of linear DNA, for example, under diluted conditions significantly increases the recovery of smaller PCR products, and improves the recovery of larger DNA fragments as well. In another embodiment, reduced vacuum pressure is used during ultrafiltration to increase the recovery of smaller PCR products and improve the recovery of larger DNA fragments as well.

US Patent:

20040182770, Sep 23, 2004

Filed:

Dec 2, 2003

Appl. No.:

10/726240

Inventors:

Phillip Clark - Wakefield MA, US
Chris Scott - Westford MA, US
Michael Colman - Beverly MA, US

International Classification:

B01D063/00

US Classification:

210/321600, 210/323100, 422/101000

Abstract:

A laboratory device design particularly for a multiplate format that includes a plate or tray having a plurality of utilitarian discontinuities such as reaction chambers or wells, wherein at least two of the discontinuities have different functionalities. In a preferred embodiment, the device is a multiwell plate or tray that meets SBS dimensional standards guidelines and is therefore automation compatible. In one embodiment, the device is a multiwell plate or tray that has a modular design, wherein removable inserts with different functionalities can be placed in a base. The particular inserts chosen depend on the desired sample preparation or assay to be carried out.

US Patent:

46088199, Sep 2, 1986

Filed:

Dec 27, 1983

Appl. No.:

6/565942

Inventors:

Michael E. Colman - Wakefield MA
Robert E. Goeller - Beverly MA

Assignee:

General Electric Company - Lynn MA

International Classification:

F02C 718

US Classification:

60 3983

Abstract:

The invention comprises a system for cooling a component in a gas turbine engine, and, in particular, for cooling an engine electronic control thereof. The cooling system includes a housing for mounting the control having a plurality of heat transfer fins extending outwardly therefrom. The housing is mounted in the engine upstream of a compressor and to a front frame having an aperture through which the fins extend. The front frame defines a flowpath to the compressor and the fins extend into the flowpath without adversely affecting the aerodynamic airflow pattern thereof. In a preferred embodiment, the fins extend substantially only to an inner surface of the front frame, and the housing includes temperature and pressure sensors disposed below root sections of the fins.

US Patent:

46012028, Jul 22, 1986

Filed:

Mar 15, 1985

Appl. No.:

6/695334

Inventors:

Michael E. Colman - Wakefield MA
Robert E. Goeller - Beverly MA

Assignee:

General Electric Company - Lynn MA

International Classification:

G01L 1914

US Classification:

73431

Abstract:

The invention comprises a system for cooling a component in a gas turbine engine, and, in particular, for cooling an engine electronic control thereof. The cooling system includes a housing for mounting the control having a plurality of heat transfer fins extending outwardly therefrom. The housing is mounted in the engine upstream of a compressor and to a front frame having an aperture through which the fins extend. The front frame defines a flowpath to the compressor and the fins extend into the flowpath without adversely affecting the aerodynamic airflow pattern thereof. In a preferred embodiment, the fins extend substantially only to an inner surface of the front frame, and the housing includes temperature and pressure sensors disposed below root sections of the fins.