Michael S Aye

US Patent:

20090092969, Apr 9, 2009

Filed:

Oct 9, 2007

Appl. No.:

11/869650

Inventors:

Michael Aye - Fountain Valley CA, US
Lilly I. Kong - Covina CA, US
Michelle M. Tabb - Santa Ana CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/00

US Classification:

435 6, 536 231

Abstract:

Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include , and

US Patent:

20090181360, Jul 16, 2009

Filed:

Dec 21, 2007

Appl. No.:

11/963699

Inventors:

Jules Chen - Walnut CA, US
Lilly I. Kong - Covina CA, US
Fan Chen - Fullerton CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.

US Patent:

20090197262, Aug 6, 2009

Filed:

May 7, 2008

Appl. No.:

12/116364

Inventors:

Michelle M. Tabb - Santa Ana CA, US
Lilly I. Kong - Covina CA, US
Ning Lu - Pleasanton CA, US
Michael Aye - Fountain Valley CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 237

Abstract:

Disclosed herein are methods and compositions for detecting and by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.

US Patent:

20090226889, Sep 10, 2009

Filed:

Jan 14, 2008

Appl. No.:

12/014063

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a biological sample comprising, wherein the target nucleic acids comprise the 5′ UTR of the enterovirus genome, UL29 of herpes simplex virus and gene 36 of Varicella-Zoster virus.

US Patent:

20130022963, Jan 24, 2013

Filed:

Jul 6, 2012

Appl. No.:

13/543336

Inventors:

MAURICE EXNER - SAN CLEMENTE CA, US
LUCA JACKY - ORANGE CA, US
HUONG MAI - IRVINE CA, US
JULES CHEN - WALNUT CA, US
MICHELLE M. TABB - SANTA ANA CA, US
MICHAEL AYE - HUNTINGTON BEACH CA, US
EMBERLEE ELEAZAR - ANAHEIM CA, US

International Classification:

C12Q 1/68
C12Q 1/70

US Classification:

435 5, 435 612, 435 611

Abstract:

Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.

US Patent:

20200340068, Oct 29, 2020

Filed:

Apr 10, 2020

Appl. No.:

16/845472

Inventors:

- Secaucus NJ, US
Luca Jacky - Orange CA, US
Huong Mai - Irvine CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Huntington Beach CA, US

Assignee:

Quest Diagnostics Investments LLC - Secaucus NJ

International Classification:

C12Q 1/70
C12Q 1/68
C12Q 1/686
C12Q 1/689
C12Q 1/6844

Abstract:

Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.

US Patent:

20200123596, Apr 23, 2020

Filed:

Oct 29, 2019

Appl. No.:

16/667092

Inventors:

- Secaucus NJ, US
Ming-Chou Lee - Mission Vlejo CA, US
Lilly I. Kong - Covina CA, US
Ning Lu - Pleasonton CA, US
Michael Aye - Fountain Valley CA, US
Fan Chen - Fullerton CA, US
Jules Chen - , US

Assignee:

Quest Diagnostics Investments LLC - Secaucus NJ

International Classification:

C12Q 1/689

Abstract:

Disclosed herein are methods and compositions for detecting and by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.

US Patent:

20170081735, Mar 23, 2017

Filed:

Oct 7, 2016

Appl. No.:

15/288291

Inventors:

- Wilmington DE, US
Luca Jacky - Orange CA, US
Huong Mai - Irvine CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Huntington Beach CA, US

Assignee:

Quest Diagnostics Investments Incorporated - Wilmington DE

International Classification:

C12Q 1/70
C12Q 1/68

Abstract:

Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods as-saying saying extracted nucleic acids.