Maurizio Denaro from Princeton, NJ, age 73

Antibiotics Ge 37468 A, B And C
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US Patent:

56187246, Apr 8, 1997
Filed:

May 16, 1996
Appl. No.:

8/648646
Inventors:

Sergio Stella - Legnano, IT
Nicoletta Montanini - Carpiano, IT
Francis J. LeMonnier - Saronno, IT
Luigi Colombo - Malnate, IT
Enrico Selva - Gropello Cairoli, IT
Maurizio Denaro - Cincinnati OH
Assignee:

Gruppo Lepetit SpA - Gerenzano
International Classification:

C12M 102
A61K 3800
US Classification:

4352534
Abstract:

The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them. The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.

Solid Phase Immunoassay To Detect Inhibitors Of Proteolytic Enzymes
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US Patent:

61597465, Dec 12, 2000
Filed:

Sep 23, 1996
Appl. No.:

8/714159
Inventors:

Khalid Islam - Como, IT
Lucia Carrano - Uboldo, IT
Maurizio Denaro - Del Mar CA
Assignee:

Gruppo Lepetit S.p.A. - Milan
International Classification:

G01N 33533
US Classification:

436518
Abstract:

Solid phase immunoassay for detecting specific inhibitors of proteolytic enzymes in biological fluids, which comprises: a) contacting a tubulin peptide covalently linked to a support with a solution containing a proteolytic activity together with a protease inhibitor, b) detecting the inhibitor activity against the selected proteases by contacting the support with a solution containing a labelled monoclonal antibody which specifically recognises the free end of the tubulin peptide linked to the support.

Antibiotics Ge 37468 A, B And C
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US Patent:

56101430, Mar 11, 1997
Filed:

Jun 21, 1995
Appl. No.:

8/493043
Inventors:

Sergio Stella - Legnano, IT
Nicoletta Montanini - Carpiano, IT
Francis J. LeMonnier - Saronno, IT
Luigi Colombo - Malnate, IT
Enrico Selva - Gropello Cairoli, IT
Maurizio Denaro - Cincinnati OH
Assignee:

Gruppo Lepetit S.p.A. - Varese
International Classification:

C07K 500
A61K 3702
US Classification:

514 18
Abstract:

The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them. The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.

Sesquiteterpenic Dervatives
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US Patent:

58540369, Dec 29, 1998
Filed:

Sep 10, 1996
Appl. No.:

8/716259
Inventors:

Stefania Stefanelli - Legnano, IT
Federica Sponga - Saronno, IT
Khalid Islam - Como, IT
Maurizio Denaro - Del Mar CA
Pietro Ferrari - Garbagnate, IT
Assignee:

Gruppo Lepetit S.p.A. - Milan
International Classification:

C12D 1704
A16K 3134
C07D30794
US Classification:

435126
Abstract:

The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3. 1. 3. 25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.

Use Of Tropolone Derivatives As Inhibitors Of The Enzyme Inositol Monophosphatase
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US Patent:

59901608, Nov 23, 1999
Filed:

May 14, 1999
Appl. No.:

9/312733
Inventors:

Khalid Islam - Como, IT
Stefania Stefanelli - Legnano, IT
Federica Sponga - Saronno, IT
Maurizio Denaro - San Diego CA
Assignee:

Gruppo Lepetit, SpA - Milan
International Classification:

A01N 3700
A61K 31185
C12Q 142
US Classification:

514470
Abstract:

The present invention concerns the use of puberulic or puberulonic acid as inhibitors of the enzyme iositol monophosphatase (EC 3. 1. 3. 25) and thus useful in the treatment of manic or depressive symptoms.

Central Venous Catheters Loaded With Antibiotics Of The Ramoplanin Group Preventing Development Of Catheter Related Infections
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US Patent:

57529418, May 19, 1998
Filed:

Aug 2, 1996
Appl. No.:

8/687413
Inventors:

Gabriella Romano' - Legnano, IT
Beth P. Goldstein - Tarrytown NY
Rosamund Jean Williams - Saronno, IT
Maurizio Denaro - Del Mar CA
Assignee:

Gruppo Lepetit S.p.A.
International Classification:

A61M 535
A61M 2500
US Classification:

604265
Abstract:

The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.

36-Derivatives Of Rifamycins And Their Use As Antimicrobial Agents
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US Patent:

57863504, Jul 28, 1998
Filed:

Jan 31, 1997
Appl. No.:

8/792035
Inventors:

Emilio Occelli - Parabiago, IT
Sergio Lociuro - Milan, IT
Romeo Ciabatti - Novate Milanese, IT
Maurizio Denaro - Cincinnati OH
Assignee:

Gruppo Lepetit S.p.A. - Milan
International Classification:

A61D 31345
C07D49108
US Classification:

514183
Abstract:

Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C. sub. 1 -C. sub. 8)alkyl, halo, hydroxy, (C. sub. 1 -C. sub. 4)acyloxy, (C. sub. 1-C. sub. 4)alkoxy, (C. sub. 1 -C. sub. 4)alkylthio, (C. sub. 1 -C. sub. 4)alkylamino, di(C. sub. 1-C. sub. 4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.

Antibiotic Ge 2270 Factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E And T
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US Patent:

57472955, May 5, 1998
Filed:

Jun 2, 1995
Appl. No.:

8/460177
Inventors:

Enrico Selva - Gropello Cairoli, IT
Paolo Tavecchia - Rho, IT
Ermenegildo Restelli - Gerenzano, IT
Pietro Ferrari - Garbagnate Milanese, IT
Maurizio Denaro - Cincinnati OH
Assignee:

Gruppo Lepetit S.p.A. - Milan
International Classification:

C12P 2104
C12P 100
US Classification:

435 713
Abstract:

The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B. sub. 1, B. sub. 2, C. sub. 1, C. sub. 2, D. sub. 1, D. sub. 2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.

Maurizio Denaro